OBOC small-molecule combinatorial library encoded by halogenated mass-tags

Sung Hee Hwang, Alan Lehman, Xin Cong, Marilyn M. Olmstead, Kit Lam, Carlito B Lebrilla, Mark J. Kurth

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Abstract

(Chemical Equation Presented) A bromine-/chlorine-containing mass-tag encoding strategy for a small-molecule OBOC combinatorial library is reported. The resulting MALDI FTMS isotope pattern of each tag clearly defines the component building blocks of each "hit" bead in an 1890-member demonstration library screened on-bead for binding against streptavidin via both enzyme-linked colorimetric and Quantum Dot/COPAS assays.

Original languageEnglish (US)
Pages (from-to)3829-3832
Number of pages4
JournalOrganic Letters
Volume6
Issue number21
DOIs
StatePublished - Oct 14 2004

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ASJC Scopus subject areas

  • Molecular Medicine

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