OBOC small-molecule combinatorial library encoded by halogenated mass-tags

Sung Hee Hwang, Alan Lehman, Xin Cong, Marilyn M. Olmstead, Kit Lam, Carlito B Lebrilla, Mark J. Kurth

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


(Chemical Equation Presented) A bromine-/chlorine-containing mass-tag encoding strategy for a small-molecule OBOC combinatorial library is reported. The resulting MALDI FTMS isotope pattern of each tag clearly defines the component building blocks of each "hit" bead in an 1890-member demonstration library screened on-bead for binding against streptavidin via both enzyme-linked colorimetric and Quantum Dot/COPAS assays.

Original languageEnglish (US)
Pages (from-to)3829-3832
Number of pages4
JournalOrganic Letters
Issue number21
StatePublished - Oct 14 2004

ASJC Scopus subject areas

  • Molecular Medicine


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