Oblique-incidence reflectivity difference microscopes for label-free high-throughput detection of biochemical reactions in microarray format

X. D. Zhu, J. P. Landry, Y. S. Sun, Jeffrey Gregg, Kit Lam, X. W. Guo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We describe recently developed oblique-incidence optical reflectivity difference microscopes for label-free/high-throughput detection of biomolecular reactions on DNA/protein microarrays. We present examples of application of this technique to DNA-DNA hybridization, antibody-antigen capture, and protein-small-molecule binding reactions.

Original languageEnglish (US)
Title of host publicationOptics InfoBase Conference Papers
PublisherOptical Society of America
ISBN (Print)1557528071, 9781557528070
StatePublished - 2006
EventBiomedical Topical Meeting, BIO 2006 - Fort Lauderdale, FL, United States
Duration: Mar 19 2006Mar 19 2006

Other

OtherBiomedical Topical Meeting, BIO 2006
CountryUnited States
CityFort Lauderdale, FL
Period3/19/063/19/06

ASJC Scopus subject areas

  • Instrumentation
  • Atomic and Molecular Physics, and Optics

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