Abstract
We describe recently developed oblique-incidence optical reflectivity difference microscopes for label-free/high-throughput detection of biomolecular reactions on DNA/protein microarrays. We present examples of application of this technique to DNA-DNA hybridization, antibody-antigen capture, and protein-small-molecule binding reactions.
| Original language | English (US) |
|---|---|
| Title of host publication | Optics InfoBase Conference Papers |
| Publisher | Optical Society of America |
| ISBN (Print) | 1557528071, 9781557528070 |
| State | Published - 2006 |
| Event | Biomedical Topical Meeting, BIO 2006 - Fort Lauderdale, FL, United States Duration: Mar 19 2006 → Mar 19 2006 |
Other
| Other | Biomedical Topical Meeting, BIO 2006 |
|---|---|
| Country | United States |
| City | Fort Lauderdale, FL |
| Period | 3/19/06 → 3/19/06 |
ASJC Scopus subject areas
- Instrumentation
- Atomic and Molecular Physics, and Optics
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Zhu, X. D., Landry, J. P., Sun, Y. S., Gregg, J., Lam, K., & Guo, X. W. (2006). Oblique-incidence reflectivity difference microscopes for label-free high-throughput detection of biochemical reactions in microarray format. In Optics InfoBase Conference Papers Optical Society of America.