Obeticholic acid for the treatment of primary biliary cirrhosis

Palak J. Trivedi, Gideon M. Hirschfield, M. Eric Gershwin

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Primary biliary cirrhosis (PBC) is characterized by progressive nonsuppurative destruction of small bile ducts, resulting in intrahepatic cholestasis, fibrosis and ultimately end-stage liver disease. Timely intervention with ursodeoxycholic acid is associated with excellent survival, although approximately one-third of all patients fail to achieve biochemical response, signifying a critical need for additional therapeutic strategies. Obeticholic acid (OCA) is a potent ligand of the nuclear hormone receptor farnesoid X receptor (FXR). Activation of FXR inhibits bile acid synthesis and protects against toxic accumulation in models of cholestasis and facilitates hepatic regeneration in preclinical studies. Data from recent Phase II and III controlled trials suggest a therapeutic impact of OCA in PBC biochemical nonresponders, as evidenced by change in proven laboratory surrogates of long-term outcome. Dose-dependent pruritus is a common adverse effect, but may be overcome through dose-titration. Longer term studies are needed with focus on safety and long-term clinical efficacy.

Original languageEnglish (US)
Pages (from-to)13-26
Number of pages14
JournalExpert Review of Clinical Pharmacology
Volume9
Issue number1
DOIs
StatePublished - Jan 2 2016

Keywords

  • autoimmune disease
  • cholangitis
  • obeticholic acid
  • primary biliary cirrhosis
  • ursodeoxycholic acid

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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