Obesity induced T cell dysfunction and implications for cancer immunotherapy

Ethan G. Aguilar, William J Murphy

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Obesity has been shown to increase risk for a number of different disorders, including cancer. In addition, obesity is also associated with immune dysfunction, which could contribute to its strong association with other comorbidities. Recently, the immune system has been found to be heavily regulated by changes in metabolism. In particular, T cells are able to respond to intrinsic metabolic regulatory mechanisms, as well as extrinsic factors such as the changes in metabolite availability. The dysfunctional metabolic environment created by obesity could therefore have a direct impact on T cell responses. In this review, we highlight recent findings in the fields of T cell biology and obesity, with a focus on mechanisms driving T cell dysfunction and potential implications for immunotherapeutic treatment of cancer.

Original languageEnglish (US)
Pages (from-to)181-186
Number of pages6
JournalCurrent Opinion in Immunology
Volume51
DOIs
StatePublished - Apr 1 2018

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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