Obesity in middle age and future risk of dementia: A 27 year longitudinal population based study

Rachel Whitmer, Erica P. Gunderson, Elizabeth Barrett-Connor, Charles P. Quesenberry, Kristine Yaffe

Research output: Contribution to journalArticle

586 Citations (Scopus)

Abstract

Objective: To evaluate any association between obesity in middle age, measured by body mass index and skinfold thickness, and risk of dementia later in life. Design: Analysis of prospective data from a multiethnic population based cohort. Setting: Kaiser Permanente Northern California Medical Group, a healthcare delivery organisation. Participants: 10 276 men and women who underwent detailed health evaluations from 1964 to 1973 when they were aged 40-45 and who were still members of the health plan in 1994. Main outcome measures: Diagnosis of dementia from January 1994 to April 2003. Time to diagnosis was analysed with Cox proportional hazard models adjusted for age, sex, race, education, smoking, alcohol use, marital status, diabetes, hypertension, hyperlipidaemia, stroke, and ischaemic heart disease. Results: Dementia was diagnosed in 713 (6.9%) participants. Obese people (body mass index ≥ 30) had a 74% increased risk of dementia (hazard ratio 1.74, 95% confidence interval 1.34 to 2.26), while overweight people (body mass index 25.0-29.9) had a 35% greater risk of dementia (1.35, 1.14 to 1.60) compared with those of normal weight (body mass index 18.6-24.9). Compared with those in the lowest fifth, men and women in the highest fifth of the distribution of subscapular or tricep skinfold thickness had a 72% and 59% greater risk of dementia, respectively (1.72, 1.36 to 2.18, and 1.59, 1.24 to 2.04). Conclusions: Obesity in middle age increases the risk of future dementia independently of comorbid conditions.

Original languageEnglish (US)
Pages (from-to)1360-1362
Number of pages3
JournalBritish Medical Journal
Volume330
Issue number7504
DOIs
StatePublished - Jun 11 2005
Externally publishedYes

Fingerprint

Dementia
Obesity
Body Mass Index
Population
Skinfold Thickness
Sex Education
Health
Marital Status
Hyperlipidemias
Proportional Hazards Models
Myocardial Ischemia
Smoking
Stroke
Alcohols
Outcome Assessment (Health Care)
Organizations
Confidence Intervals
Hypertension
Delivery of Health Care
Weights and Measures

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Obesity in middle age and future risk of dementia : A 27 year longitudinal population based study. / Whitmer, Rachel; Gunderson, Erica P.; Barrett-Connor, Elizabeth; Quesenberry, Charles P.; Yaffe, Kristine.

In: British Medical Journal, Vol. 330, No. 7504, 11.06.2005, p. 1360-1362.

Research output: Contribution to journalArticle

Whitmer, Rachel ; Gunderson, Erica P. ; Barrett-Connor, Elizabeth ; Quesenberry, Charles P. ; Yaffe, Kristine. / Obesity in middle age and future risk of dementia : A 27 year longitudinal population based study. In: British Medical Journal. 2005 ; Vol. 330, No. 7504. pp. 1360-1362.
@article{9c19f7e730cd4286987c8e747a832fd8,
title = "Obesity in middle age and future risk of dementia: A 27 year longitudinal population based study",
abstract = "Objective: To evaluate any association between obesity in middle age, measured by body mass index and skinfold thickness, and risk of dementia later in life. Design: Analysis of prospective data from a multiethnic population based cohort. Setting: Kaiser Permanente Northern California Medical Group, a healthcare delivery organisation. Participants: 10 276 men and women who underwent detailed health evaluations from 1964 to 1973 when they were aged 40-45 and who were still members of the health plan in 1994. Main outcome measures: Diagnosis of dementia from January 1994 to April 2003. Time to diagnosis was analysed with Cox proportional hazard models adjusted for age, sex, race, education, smoking, alcohol use, marital status, diabetes, hypertension, hyperlipidaemia, stroke, and ischaemic heart disease. Results: Dementia was diagnosed in 713 (6.9{\%}) participants. Obese people (body mass index ≥ 30) had a 74{\%} increased risk of dementia (hazard ratio 1.74, 95{\%} confidence interval 1.34 to 2.26), while overweight people (body mass index 25.0-29.9) had a 35{\%} greater risk of dementia (1.35, 1.14 to 1.60) compared with those of normal weight (body mass index 18.6-24.9). Compared with those in the lowest fifth, men and women in the highest fifth of the distribution of subscapular or tricep skinfold thickness had a 72{\%} and 59{\%} greater risk of dementia, respectively (1.72, 1.36 to 2.18, and 1.59, 1.24 to 2.04). Conclusions: Obesity in middle age increases the risk of future dementia independently of comorbid conditions.",
author = "Rachel Whitmer and Gunderson, {Erica P.} and Elizabeth Barrett-Connor and Quesenberry, {Charles P.} and Kristine Yaffe",
year = "2005",
month = "6",
day = "11",
doi = "10.1136/bmj.38446.466238.E0",
language = "English (US)",
volume = "330",
pages = "1360--1362",
journal = "The BMJ",
issn = "0959-8146",
publisher = "BMJ Publishing Group",
number = "7504",

}

TY - JOUR

T1 - Obesity in middle age and future risk of dementia

T2 - A 27 year longitudinal population based study

AU - Whitmer, Rachel

AU - Gunderson, Erica P.

AU - Barrett-Connor, Elizabeth

AU - Quesenberry, Charles P.

AU - Yaffe, Kristine

PY - 2005/6/11

Y1 - 2005/6/11

N2 - Objective: To evaluate any association between obesity in middle age, measured by body mass index and skinfold thickness, and risk of dementia later in life. Design: Analysis of prospective data from a multiethnic population based cohort. Setting: Kaiser Permanente Northern California Medical Group, a healthcare delivery organisation. Participants: 10 276 men and women who underwent detailed health evaluations from 1964 to 1973 when they were aged 40-45 and who were still members of the health plan in 1994. Main outcome measures: Diagnosis of dementia from January 1994 to April 2003. Time to diagnosis was analysed with Cox proportional hazard models adjusted for age, sex, race, education, smoking, alcohol use, marital status, diabetes, hypertension, hyperlipidaemia, stroke, and ischaemic heart disease. Results: Dementia was diagnosed in 713 (6.9%) participants. Obese people (body mass index ≥ 30) had a 74% increased risk of dementia (hazard ratio 1.74, 95% confidence interval 1.34 to 2.26), while overweight people (body mass index 25.0-29.9) had a 35% greater risk of dementia (1.35, 1.14 to 1.60) compared with those of normal weight (body mass index 18.6-24.9). Compared with those in the lowest fifth, men and women in the highest fifth of the distribution of subscapular or tricep skinfold thickness had a 72% and 59% greater risk of dementia, respectively (1.72, 1.36 to 2.18, and 1.59, 1.24 to 2.04). Conclusions: Obesity in middle age increases the risk of future dementia independently of comorbid conditions.

AB - Objective: To evaluate any association between obesity in middle age, measured by body mass index and skinfold thickness, and risk of dementia later in life. Design: Analysis of prospective data from a multiethnic population based cohort. Setting: Kaiser Permanente Northern California Medical Group, a healthcare delivery organisation. Participants: 10 276 men and women who underwent detailed health evaluations from 1964 to 1973 when they were aged 40-45 and who were still members of the health plan in 1994. Main outcome measures: Diagnosis of dementia from January 1994 to April 2003. Time to diagnosis was analysed with Cox proportional hazard models adjusted for age, sex, race, education, smoking, alcohol use, marital status, diabetes, hypertension, hyperlipidaemia, stroke, and ischaemic heart disease. Results: Dementia was diagnosed in 713 (6.9%) participants. Obese people (body mass index ≥ 30) had a 74% increased risk of dementia (hazard ratio 1.74, 95% confidence interval 1.34 to 2.26), while overweight people (body mass index 25.0-29.9) had a 35% greater risk of dementia (1.35, 1.14 to 1.60) compared with those of normal weight (body mass index 18.6-24.9). Compared with those in the lowest fifth, men and women in the highest fifth of the distribution of subscapular or tricep skinfold thickness had a 72% and 59% greater risk of dementia, respectively (1.72, 1.36 to 2.18, and 1.59, 1.24 to 2.04). Conclusions: Obesity in middle age increases the risk of future dementia independently of comorbid conditions.

UR - http://www.scopus.com/inward/record.url?scp=20544462061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20544462061&partnerID=8YFLogxK

U2 - 10.1136/bmj.38446.466238.E0

DO - 10.1136/bmj.38446.466238.E0

M3 - Article

C2 - 15863436

AN - SCOPUS:20544462061

VL - 330

SP - 1360

EP - 1362

JO - The BMJ

JF - The BMJ

SN - 0959-8146

IS - 7504

ER -