Obesity and increased contractile activity influence the protein content of UCP2 in human skeletal muscle

Jean Aimé Simoneau, D. E. Kelley, Craig H Warden

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The newly discovered uncoupling protein-2 (UCP2) has been proposed to play a critical role in thermoregulatory and substrate oxidation processes. Skeletal muscle mRNA expression and, more recently, the protein content of UCP2 were investigated in humans. These studies have shown that the content of this protein varies quite substantially and that several factors could be responsible for its variation in human skeletal muscle. The aim of this review is to determine whether obesity and low-intensity increased contractile activity contribute to variation in muscle UCP2 content. A recent study from our laboratories revealed that, in obesity, UCP2 content in skeletal muscle is overexpressed by about 1.5-fold compared to lean. Body weight loss in obese subjects did not cause any change in skeletal muscle UCP2 content. On the other hand, when increased muscular contractile activity of knee extensor muscles is induced by several weeks of low-frequency electrical stimulation, UCP2 content increased by about 15%. Obesity and increased contractile activity do not appear sufficient, however, to explain the magnitude of the human skeletal muscle variation in UCP2 content. Since intensive efforts are being devoted to this area of research, it is expected that our understanding of the causes contributing to its variation in humans will soon be substantially improved.

Original languageEnglish (US)
JournalInternational Journal of Obesity
Volume23
Issue numberSUPPL. 6
StatePublished - 1999

Fingerprint

skeletal muscle
Skeletal Muscle
obesity
Obesity
protein content
muscle protein
Proteins
proteins
Muscle Proteins
knees
weight loss
Uncoupling Protein 2
oxidation
Electric Stimulation
muscles
Weight Loss
Knee
body weight
Body Weight
Muscles

Keywords

  • Body weight loss
  • Muscular contractile activity
  • Obesity
  • Skeletal muscle
  • UCP2

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Obesity and increased contractile activity influence the protein content of UCP2 in human skeletal muscle. / Simoneau, Jean Aimé; Kelley, D. E.; Warden, Craig H.

In: International Journal of Obesity, Vol. 23, No. SUPPL. 6, 1999.

Research output: Contribution to journalArticle

@article{5ed7fbebd30341dd9b2e63e7fac577b7,
title = "Obesity and increased contractile activity influence the protein content of UCP2 in human skeletal muscle",
abstract = "The newly discovered uncoupling protein-2 (UCP2) has been proposed to play a critical role in thermoregulatory and substrate oxidation processes. Skeletal muscle mRNA expression and, more recently, the protein content of UCP2 were investigated in humans. These studies have shown that the content of this protein varies quite substantially and that several factors could be responsible for its variation in human skeletal muscle. The aim of this review is to determine whether obesity and low-intensity increased contractile activity contribute to variation in muscle UCP2 content. A recent study from our laboratories revealed that, in obesity, UCP2 content in skeletal muscle is overexpressed by about 1.5-fold compared to lean. Body weight loss in obese subjects did not cause any change in skeletal muscle UCP2 content. On the other hand, when increased muscular contractile activity of knee extensor muscles is induced by several weeks of low-frequency electrical stimulation, UCP2 content increased by about 15{\%}. Obesity and increased contractile activity do not appear sufficient, however, to explain the magnitude of the human skeletal muscle variation in UCP2 content. Since intensive efforts are being devoted to this area of research, it is expected that our understanding of the causes contributing to its variation in humans will soon be substantially improved.",
keywords = "Body weight loss, Muscular contractile activity, Obesity, Skeletal muscle, UCP2",
author = "Simoneau, {Jean Aim{\'e}} and Kelley, {D. E.} and Warden, {Craig H}",
year = "1999",
language = "English (US)",
volume = "23",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",
number = "SUPPL. 6",

}

TY - JOUR

T1 - Obesity and increased contractile activity influence the protein content of UCP2 in human skeletal muscle

AU - Simoneau, Jean Aimé

AU - Kelley, D. E.

AU - Warden, Craig H

PY - 1999

Y1 - 1999

N2 - The newly discovered uncoupling protein-2 (UCP2) has been proposed to play a critical role in thermoregulatory and substrate oxidation processes. Skeletal muscle mRNA expression and, more recently, the protein content of UCP2 were investigated in humans. These studies have shown that the content of this protein varies quite substantially and that several factors could be responsible for its variation in human skeletal muscle. The aim of this review is to determine whether obesity and low-intensity increased contractile activity contribute to variation in muscle UCP2 content. A recent study from our laboratories revealed that, in obesity, UCP2 content in skeletal muscle is overexpressed by about 1.5-fold compared to lean. Body weight loss in obese subjects did not cause any change in skeletal muscle UCP2 content. On the other hand, when increased muscular contractile activity of knee extensor muscles is induced by several weeks of low-frequency electrical stimulation, UCP2 content increased by about 15%. Obesity and increased contractile activity do not appear sufficient, however, to explain the magnitude of the human skeletal muscle variation in UCP2 content. Since intensive efforts are being devoted to this area of research, it is expected that our understanding of the causes contributing to its variation in humans will soon be substantially improved.

AB - The newly discovered uncoupling protein-2 (UCP2) has been proposed to play a critical role in thermoregulatory and substrate oxidation processes. Skeletal muscle mRNA expression and, more recently, the protein content of UCP2 were investigated in humans. These studies have shown that the content of this protein varies quite substantially and that several factors could be responsible for its variation in human skeletal muscle. The aim of this review is to determine whether obesity and low-intensity increased contractile activity contribute to variation in muscle UCP2 content. A recent study from our laboratories revealed that, in obesity, UCP2 content in skeletal muscle is overexpressed by about 1.5-fold compared to lean. Body weight loss in obese subjects did not cause any change in skeletal muscle UCP2 content. On the other hand, when increased muscular contractile activity of knee extensor muscles is induced by several weeks of low-frequency electrical stimulation, UCP2 content increased by about 15%. Obesity and increased contractile activity do not appear sufficient, however, to explain the magnitude of the human skeletal muscle variation in UCP2 content. Since intensive efforts are being devoted to this area of research, it is expected that our understanding of the causes contributing to its variation in humans will soon be substantially improved.

KW - Body weight loss

KW - Muscular contractile activity

KW - Obesity

KW - Skeletal muscle

KW - UCP2

UR - http://www.scopus.com/inward/record.url?scp=0033062792&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033062792&partnerID=8YFLogxK

M3 - Article

VL - 23

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - SUPPL. 6

ER -