Obesity and cardiovascular disease: Pathophysiology, evaluation, and effect of weight loss

Paul Poirier, Thomas D. Giles, George A. Bray, Yuling Hong, Judith S. Stern, F. Xavier Pi-Sunyer, Robert H. Eckel

Research output: Contribution to journalArticle

488 Scopus citations

Abstract

Obesity is becoming a global epidemic in both children and adults, and it is associated with numerous co-morbidities such as cardiovascular diseases (CVD), type 2 diabetes, hypertension, certain cancers, and sleep apnea/sleep-disordered breathing. In fact, is an independent risk factor for CVD and CVD risks have been also documented in obese children, and is associated with reduced life expectancy. A variety of adaptations/alterations in cardiac structure and function occur in the individual as adipose tissue accumulates in excess amount. As a whole, overweight/obesity predispose or is associated with numerous cardiac complications such as coronary heart disease, heart failure, and sudden death through its impact on the cardiovascular system.

Original languageEnglish (US)
Pages (from-to)968-976
Number of pages9
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume26
Issue number5
DOIs
StatePublished - May 2006
Externally publishedYes

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Keywords

  • Congestive heart failure
  • Myocardial biology, structure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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