OARSI Clinical Trials Recommendations: Design and conduct of clinical trials for hip osteoarthritis

Nancy E Lane, M. C. Hochberg, M. C. Nevitt, L. S. Simon, A. E. Nelson, M. Doherty, Y. Henrotin, K. Flechsenhar

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The ability to assess the efficacy and effectiveness of an intervention for the treatment of hip osteoarthritis (OA) requires strong clinical trial methodology. This consensus paper provides recommendations based on a narrative literature review and best judgment of the members of the committee for clinical trials of hip OA. We provide recommendations on clinical trial design, outcome measures, including structural (radiography), and patient and physician global assessments, performance based measures, molecular markers and experimental endpoints including MRI imaging. This information can be utilized by sponsors of trials for new therapeutic agents for hip OA.

Original languageEnglish (US)
Pages (from-to)761-771
Number of pages11
JournalOsteoarthritis and Cartilage
Volume23
Issue number5
DOIs
StatePublished - 2015

Keywords

  • Clinical trial
  • Hip
  • Osteoarthritis

ASJC Scopus subject areas

  • Biomedical Engineering
  • Orthopedics and Sports Medicine
  • Rheumatology

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    Lane, N. E., Hochberg, M. C., Nevitt, M. C., Simon, L. S., Nelson, A. E., Doherty, M., Henrotin, Y., & Flechsenhar, K. (2015). OARSI Clinical Trials Recommendations: Design and conduct of clinical trials for hip osteoarthritis. Osteoarthritis and Cartilage, 23(5), 761-771. https://doi.org/10.1016/j.joca.2015.03.006