Nutritional lipidomics: Molecular metabolism, analytics, and diagnostics

Jennifer T. Smilowitz, Angela M. Zivkovic, Yu-Jui Yvonne Wan, Steve M. Watkins, Malin L. Nording, Bruce D. Hammock, J. Bruce German

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The field of lipidomics is providing nutritional science a more comprehensive view of lipid intermediates. Lipidomics research takes advantage of the increase in accuracy and sensitivity of mass detection of MS with new bioinformatics toolsets to characterize the structures and abundances of complex lipids. Yet, translating lipidomics to practice via nutritional interventions is still in its infancy. No single instrumentation platform is able to solve the varying analytical challenges of the different molecular lipid species. Biochemical pathways of lipid metabolism remain incomplete and the tools to map lipid compositional data to pathways are still being assembled. Biology itself is dauntingly complex and simply separating biological structures remains a key challenge to lipidomics. Nonetheless, the strategy of combining tandem analytical methods to perform the sensitive, high-throughput, quantitative, and comprehensive analysis of lipid metabolites of very large numbers of molecules is poised to drive the field forward rapidly. Among the next steps for nutrition to understand the changes in structures, compositions, and function of lipid biomolecules in response to diet is to describe their distribution within discrete functional compartments lipoproteins. Additionally, lipidomics must tackle the task of assigning the functions of lipids as signaling molecules, nutrient sensors, and intermediates of metabolic pathways.

Original languageEnglish (US)
Pages (from-to)1319-1335
Number of pages17
JournalMolecular Nutrition and Food Research
Volume57
Issue number8
DOIs
StatePublished - Aug 2013

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Keywords

  • Bile acids
  • Lipids
  • Mass spectrometry
  • Nutrition
  • Oxylipins

ASJC Scopus subject areas

  • Food Science
  • Biotechnology

Cite this

Smilowitz, J. T., Zivkovic, A. M., Wan, Y-J. Y., Watkins, S. M., Nording, M. L., Hammock, B. D., & German, J. B. (2013). Nutritional lipidomics: Molecular metabolism, analytics, and diagnostics. Molecular Nutrition and Food Research, 57(8), 1319-1335. https://doi.org/10.1002/mnfr.201200808