Nutritional Ketosis for Weight Management and Reversal of Metabolic Syndrome

Victoria M. Gershuni, Stephanie L. Yan, Valentina Medici

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Purpose of Review: The goal of this paper is to review current literature on nutritional ketosis within the context of weight management and metabolic syndrome, namely, insulin resistance, lipid profile, cardiovascular disease risk, and development of non-alcoholic fatty liver disease. We provide background on the mechanism of ketogenesis and describe nutritional ketosis. Recent Findings: Nutritional ketosis has been found to improve metabolic and inflammatory markers, including lipids, HbA1c, high-sensitivity CRP, fasting insulin and glucose levels, and aid in weight management. We discuss these findings and elaborate on potential mechanisms of ketones for promoting weight loss, decreasing hunger, and increasing satiety. Summary: Humans have evolved with the capacity for metabolic flexibility and the ability to use ketones for fuel. During states of low dietary carbohydrate intake, insulin levels remain low and ketogenesis takes place. These conditions promote breakdown of excess fat stores, sparing of lean muscle, and improvement in insulin sensitivity.

Original languageEnglish (US)
Pages (from-to)97-106
Number of pages10
JournalCurrent Nutrition Reports
Volume7
Issue number3
DOIs
StatePublished - Sep 1 2018

Fingerprint

Ketosis
ketosis
metabolic syndrome
weight control
ketones
Ketones
Weights and Measures
insulin resistance
Insulin Resistance
insulin
lipids
Insulin
Dietary Carbohydrates
Lipids
glycohemoglobin
Aptitude
carbohydrate intake
Hunger
dietary carbohydrate
fatty liver

Keywords

  • Glucose metabolism
  • Insulin resistance
  • Ketogenesis
  • Ketogenic diet
  • Ketone bodies
  • Low-carbohydrate diet
  • Metabolic syndrome
  • Nutritional ketosis
  • Weight loss

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Nutritional Ketosis for Weight Management and Reversal of Metabolic Syndrome. / Gershuni, Victoria M.; Yan, Stephanie L.; Medici, Valentina.

In: Current Nutrition Reports, Vol. 7, No. 3, 01.09.2018, p. 97-106.

Research output: Contribution to journalReview article

Gershuni, Victoria M. ; Yan, Stephanie L. ; Medici, Valentina. / Nutritional Ketosis for Weight Management and Reversal of Metabolic Syndrome. In: Current Nutrition Reports. 2018 ; Vol. 7, No. 3. pp. 97-106.
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