Nutritional importance of pyrroloquinoline quinone

John Killgore, Carsten Smidt, Lisa Duich, Nadia Romero-Chapman, Donald Tinker, Karen Reiser, Maria Melko, Dallas Hyde, Robert B. Rucker

Research output: Contribution to journalArticle

153 Scopus citations

Abstract

Mice fed a chemically defined diet devoid of pyrroloquinoline quinone (PQQ) grew poorly, failed to reproduce, and became osteolathyritic. Moreover, severely affected mice had friable skin, skin collagen that was readily extractable into neutral salt solutions, and decreased lysyl oxidase. The identification of functional defects in connective tissue and the growth retardation associated with PQQdeprivation suggest that PQQ plays a fimdamental role as a growth factor or vitamin.

Original languageEnglish (US)
Pages (from-to)850-852
Number of pages3
JournalScience
Volume245
Issue number4920
StatePublished - 1989

ASJC Scopus subject areas

  • General

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    Killgore, J., Smidt, C., Duich, L., Romero-Chapman, N., Tinker, D., Reiser, K., Melko, M., Hyde, D., & Rucker, R. B. (1989). Nutritional importance of pyrroloquinoline quinone. Science, 245(4920), 850-852.