Nutritional importance of pyrroloquinoline quinone

John Killgore, Carsten Smidt, Lisa Duich, Nadia Romero-Chapman, Donald Tinker, Karen Reiser, Maria Melko, Dallas Hyde, Robert B. Rucker

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

Mice fed a chemically defined diet devoid of pyrroloquinoline quinone (PQQ) grew poorly, failed to reproduce, and became osteolathyritic. Moreover, severely affected mice had friable skin, skin collagen that was readily extractable into neutral salt solutions, and decreased lysyl oxidase. The identification of functional defects in connective tissue and the growth retardation associated with PQQdeprivation suggest that PQQ plays a fimdamental role as a growth factor or vitamin.

Original languageEnglish (US)
Pages (from-to)850-852
Number of pages3
JournalScience
Volume245
Issue number4920
StatePublished - 1989

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PQQ Cofactor
Protein-Lysine 6-Oxidase
Formulated Food
Skin
Vitamins
Connective Tissue
Intercellular Signaling Peptides and Proteins
Collagen
Salts
Growth

ASJC Scopus subject areas

  • General

Cite this

Killgore, J., Smidt, C., Duich, L., Romero-Chapman, N., Tinker, D., Reiser, K., ... Rucker, R. B. (1989). Nutritional importance of pyrroloquinoline quinone. Science, 245(4920), 850-852.

Nutritional importance of pyrroloquinoline quinone. / Killgore, John; Smidt, Carsten; Duich, Lisa; Romero-Chapman, Nadia; Tinker, Donald; Reiser, Karen; Melko, Maria; Hyde, Dallas; Rucker, Robert B.

In: Science, Vol. 245, No. 4920, 1989, p. 850-852.

Research output: Contribution to journalArticle

Killgore, J, Smidt, C, Duich, L, Romero-Chapman, N, Tinker, D, Reiser, K, Melko, M, Hyde, D & Rucker, RB 1989, 'Nutritional importance of pyrroloquinoline quinone', Science, vol. 245, no. 4920, pp. 850-852.
Killgore J, Smidt C, Duich L, Romero-Chapman N, Tinker D, Reiser K et al. Nutritional importance of pyrroloquinoline quinone. Science. 1989;245(4920):850-852.
Killgore, John ; Smidt, Carsten ; Duich, Lisa ; Romero-Chapman, Nadia ; Tinker, Donald ; Reiser, Karen ; Melko, Maria ; Hyde, Dallas ; Rucker, Robert B. / Nutritional importance of pyrroloquinoline quinone. In: Science. 1989 ; Vol. 245, No. 4920. pp. 850-852.
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