Abstract
Indispensable amino acids are neither synthesized nor stored in animals and are rapidly depleted when not provided by the diet. To maintain homeostasis, organisms must sense deficiency of an indispensable amino acid and implement a repletion strategy. In rats and birds, the anterior piriform cortex houses the detector, but its mechanism has evaded description for >50 years. Recently, rapid detection of amino acid depletion was shown behaviorally when naïve animals, pre-fed a low nitrogen diet, terminated their first deficient meal within 20 min. The general amino acid control system of yeast, which is activated by amino acid deprivation via deacylated tRNA, was found to be active in rodent brain, showing conservation of amino acid sensory mechanisms across eukaryotic species.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 91-99 |
| Number of pages | 9 |
| Journal | Trends in Neurosciences |
| Volume | 29 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2006 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Nutritional homeostasis and indispensable amino acid sensing : A new solution to an old puzzle. / Gietzen, Dorothy W.; Rogers, Quinton.
In: Trends in Neurosciences, Vol. 29, No. 2, 01.02.2006, p. 91-99.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Nutritional homeostasis and indispensable amino acid sensing
T2 - A new solution to an old puzzle
AU - Gietzen, Dorothy W.
AU - Rogers, Quinton
PY - 2006/2/1
Y1 - 2006/2/1
N2 - Indispensable amino acids are neither synthesized nor stored in animals and are rapidly depleted when not provided by the diet. To maintain homeostasis, organisms must sense deficiency of an indispensable amino acid and implement a repletion strategy. In rats and birds, the anterior piriform cortex houses the detector, but its mechanism has evaded description for >50 years. Recently, rapid detection of amino acid depletion was shown behaviorally when naïve animals, pre-fed a low nitrogen diet, terminated their first deficient meal within 20 min. The general amino acid control system of yeast, which is activated by amino acid deprivation via deacylated tRNA, was found to be active in rodent brain, showing conservation of amino acid sensory mechanisms across eukaryotic species.
AB - Indispensable amino acids are neither synthesized nor stored in animals and are rapidly depleted when not provided by the diet. To maintain homeostasis, organisms must sense deficiency of an indispensable amino acid and implement a repletion strategy. In rats and birds, the anterior piriform cortex houses the detector, but its mechanism has evaded description for >50 years. Recently, rapid detection of amino acid depletion was shown behaviorally when naïve animals, pre-fed a low nitrogen diet, terminated their first deficient meal within 20 min. The general amino acid control system of yeast, which is activated by amino acid deprivation via deacylated tRNA, was found to be active in rodent brain, showing conservation of amino acid sensory mechanisms across eukaryotic species.
UR - http://www.scopus.com/inward/record.url?scp=32044443648&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=32044443648&partnerID=8YFLogxK
U2 - 10.1016/j.tins.2005.12.007
DO - 10.1016/j.tins.2005.12.007
M3 - Review article
C2 - 16406138
AN - SCOPUS:32044443648
VL - 29
SP - 91
EP - 99
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - 2
ER -