Nutritional homeostasis and indispensable amino acid sensing: A new solution to an old puzzle

Dorothy W. Gietzen, Quinton Rogers

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

Indispensable amino acids are neither synthesized nor stored in animals and are rapidly depleted when not provided by the diet. To maintain homeostasis, organisms must sense deficiency of an indispensable amino acid and implement a repletion strategy. In rats and birds, the anterior piriform cortex houses the detector, but its mechanism has evaded description for >50 years. Recently, rapid detection of amino acid depletion was shown behaviorally when naïve animals, pre-fed a low nitrogen diet, terminated their first deficient meal within 20 min. The general amino acid control system of yeast, which is activated by amino acid deprivation via deacylated tRNA, was found to be active in rodent brain, showing conservation of amino acid sensory mechanisms across eukaryotic species.

Original languageEnglish (US)
Pages (from-to)91-99
Number of pages9
JournalTrends in Neurosciences
Volume29
Issue number2
DOIs
StatePublished - Feb 1 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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