Nutritional genomics

The next frontier in the postgenomic era

Jim Kaput, Raymond L. Rodriguez

Research output: Contribution to journalArticle

258 Citations (Scopus)

Abstract

The interface between the nutritional environment and cellular/genetic processes is being referred to as "nutrigenomics." Nutrigenomics seeks to provide a molecular genetic understanding for how common dietary chemicals (i.e., nutrition) affect health by altering the expression and/or structure of an individual's genetic makeup. The fundamental concepts of the field are that the progression from a healthy phenotype to a chronic disease phenotype must occur by changes in gene expression or by differences in activities of proteins and enzymes and that dietary chemicals directly or indirectly regulate the expression of genomic information. We present a conceptual basis and specific examples for this new branch of genomic research that focuses on the tenets of nutritional genomics: 1) common dietary chemicals act on the human genome, either directly or indirectly, to alter gene expression or structure; 2) under certain circumstances and in some individuals, diet can be a serious risk factor for a number of diseases; 3) some diet-regulated genes (and their normal, common variants) are likely to play a role in the onset, incidence, progression, and/or severity of chronic diseases; 4) the degree to which diet influences the balance between healthy and disease states may depend on an individual's genetic makeup; and 5) dietary intervention based on knowledge of nutritional requirement, nutritional status, and genotype (i.e., "individualized nutrition") can be used to prevent, mitigate, or cure chronic disease.

Original languageEnglish (US)
Pages (from-to)166-177
Number of pages12
JournalPhysiological Genomics
Volume16
DOIs
StatePublished - Apr 2004

Fingerprint

Nutrigenomics
Chronic Disease
Diet
Genetic Phenomena
Phenotype
Gene Expression
Nutritional Requirements
Dietary Proteins
Genetic Structures
Human Genome
Nutritional Status
Molecular Biology
Genotype
Incidence
Health
Enzymes
Research
Genes

Keywords

  • Diet
  • Diet-regulated genes
  • Gene expression
  • Nutrition

ASJC Scopus subject areas

  • Physiology
  • Genetics

Cite this

Nutritional genomics : The next frontier in the postgenomic era. / Kaput, Jim; Rodriguez, Raymond L.

In: Physiological Genomics, Vol. 16, 04.2004, p. 166-177.

Research output: Contribution to journalArticle

Kaput, Jim ; Rodriguez, Raymond L. / Nutritional genomics : The next frontier in the postgenomic era. In: Physiological Genomics. 2004 ; Vol. 16. pp. 166-177.
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