Nutritional and physiologic significance of α-lactalbumin in infants

Bo Lönnerdal, Eric L. Lien

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

α-Lactalbumin is the major protein in breast milk (20-25% of total protein) and has been described to have several physiologic functions in the neonatal period. In the mammary gland, it participates in lactose synthesis, thereby creating an osmotic "drag" to facilitate milk production and secretion. α-Lactalbumin binds divalent cations (Ca, Zn) and may facilitate the absorption of essential minerals, and it provides a well-balanced supply of essential amino acids to the growing infant. During its digestion, peptides appear to be transiently formed that have antibacterial and immunostimulatory properties, thereby possibly aiding in the protection against infection. A novel folding variant ("molten globule state") of multimeric α-lactalbumin has recently been discovered that has anti-infective activity and enhances apoptosis, thus possibly affecting mucosal cell turnover and proliferation. Cow milk also contains α-lactalbumin, albeit less than human milk (2-5% of total protein in bovine milk), and protein fractions enriched with α-lactalbumin may now be added to infant formula to provide some of the benefits of human α-lactalbumin.

Original languageEnglish (US)
Pages (from-to)295-305
Number of pages11
JournalNutrition Reviews
Volume61
Issue number9
DOIs
StatePublished - Sep 1 2003

Fingerprint

Lactalbumin
lactalbumin
Human Milk
breast milk
Milk
proteins
milk secretion
milk
Infant Formula
Proteins
Essential Amino Acids
Milk Proteins
Divalent Cations
infant formulas
Human Mammary Glands
Lactose
essential amino acids
mammary glands
lactose
Minerals

Keywords

  • α-lactalbumin
  • Cow milk
  • Human milk
  • Infant formula

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Nutritional and physiologic significance of α-lactalbumin in infants. / Lönnerdal, Bo; Lien, Eric L.

In: Nutrition Reviews, Vol. 61, No. 9, 01.09.2003, p. 295-305.

Research output: Contribution to journalArticle

Lönnerdal, Bo ; Lien, Eric L. / Nutritional and physiologic significance of α-lactalbumin in infants. In: Nutrition Reviews. 2003 ; Vol. 61, No. 9. pp. 295-305.
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