Nutritional and metabolic responses to arginine deficeincy in carnivores

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The metabolic basis for the high dietary arginine requirement of the cat appears to be primarily the low activity of the enzyme pyrroline-5-carboxylate synthase (P5C synthase) in the intestinal mucosa. P5C synthase is required for de novo production of glutamyl-γ-semialdehyde, the immediate precursor for the synthesis of ornithine from glutamate. The next enzyme in ornithine synthesis, ornithine aminotransferse, in the cat intestinal mucosa shows low activity, which provides an additional barrier to ornithine and citrulline formation. It is suggested that the low activities of these enzymes corroborate other evidence that indicates that the cat evolved as a strict carnivore. The dog has a requirement for arginine intermediate between the cat and the rat, which is consistent with the dog having an omnivorous diet during its evolution. It is suggested that during periods of fasting, depletion of urea cycle intermediates in the cat results in some conservation of nitrogen while maintaining urea cycle enzymes at a relatively high level. However, after ingestion of animal protein (and arginine) the urea cycle of cats is capable of rapidly responding to the ammonia load, which rises from the deamination of amino acids. By this method of regulation the cat can respond to short-term fluctuations in protein intake.

Original languageEnglish (US)
Pages (from-to)524-531
Number of pages8
JournalJournal of Nutrition
Volume115
Issue number4
DOIs
StatePublished - Jan 1 1985

Fingerprint

Arginine
Cats
Ornithine
Ornithine-Oxo-Acid Transaminase
Urea
Enzymes
Intestinal Mucosa
Dogs
Nutritional Requirements
Citrulline
Deamination
Ammonia
Glutamic Acid
Fasting
Proteins
Nitrogen
Eating
Diet
Amino Acids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Nutritional and metabolic responses to arginine deficeincy in carnivores. / Morris, James.

In: Journal of Nutrition, Vol. 115, No. 4, 01.01.1985, p. 524-531.

Research output: Contribution to journalArticle

@article{996df56d7d67462abb40f74310b5260a,
title = "Nutritional and metabolic responses to arginine deficeincy in carnivores",
abstract = "The metabolic basis for the high dietary arginine requirement of the cat appears to be primarily the low activity of the enzyme pyrroline-5-carboxylate synthase (P5C synthase) in the intestinal mucosa. P5C synthase is required for de novo production of glutamyl-γ-semialdehyde, the immediate precursor for the synthesis of ornithine from glutamate. The next enzyme in ornithine synthesis, ornithine aminotransferse, in the cat intestinal mucosa shows low activity, which provides an additional barrier to ornithine and citrulline formation. It is suggested that the low activities of these enzymes corroborate other evidence that indicates that the cat evolved as a strict carnivore. The dog has a requirement for arginine intermediate between the cat and the rat, which is consistent with the dog having an omnivorous diet during its evolution. It is suggested that during periods of fasting, depletion of urea cycle intermediates in the cat results in some conservation of nitrogen while maintaining urea cycle enzymes at a relatively high level. However, after ingestion of animal protein (and arginine) the urea cycle of cats is capable of rapidly responding to the ammonia load, which rises from the deamination of amino acids. By this method of regulation the cat can respond to short-term fluctuations in protein intake.",
author = "James Morris",
year = "1985",
month = "1",
day = "1",
doi = "10.1093/jn/115.4.524",
language = "English (US)",
volume = "115",
pages = "524--531",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "4",

}

TY - JOUR

T1 - Nutritional and metabolic responses to arginine deficeincy in carnivores

AU - Morris, James

PY - 1985/1/1

Y1 - 1985/1/1

N2 - The metabolic basis for the high dietary arginine requirement of the cat appears to be primarily the low activity of the enzyme pyrroline-5-carboxylate synthase (P5C synthase) in the intestinal mucosa. P5C synthase is required for de novo production of glutamyl-γ-semialdehyde, the immediate precursor for the synthesis of ornithine from glutamate. The next enzyme in ornithine synthesis, ornithine aminotransferse, in the cat intestinal mucosa shows low activity, which provides an additional barrier to ornithine and citrulline formation. It is suggested that the low activities of these enzymes corroborate other evidence that indicates that the cat evolved as a strict carnivore. The dog has a requirement for arginine intermediate between the cat and the rat, which is consistent with the dog having an omnivorous diet during its evolution. It is suggested that during periods of fasting, depletion of urea cycle intermediates in the cat results in some conservation of nitrogen while maintaining urea cycle enzymes at a relatively high level. However, after ingestion of animal protein (and arginine) the urea cycle of cats is capable of rapidly responding to the ammonia load, which rises from the deamination of amino acids. By this method of regulation the cat can respond to short-term fluctuations in protein intake.

AB - The metabolic basis for the high dietary arginine requirement of the cat appears to be primarily the low activity of the enzyme pyrroline-5-carboxylate synthase (P5C synthase) in the intestinal mucosa. P5C synthase is required for de novo production of glutamyl-γ-semialdehyde, the immediate precursor for the synthesis of ornithine from glutamate. The next enzyme in ornithine synthesis, ornithine aminotransferse, in the cat intestinal mucosa shows low activity, which provides an additional barrier to ornithine and citrulline formation. It is suggested that the low activities of these enzymes corroborate other evidence that indicates that the cat evolved as a strict carnivore. The dog has a requirement for arginine intermediate between the cat and the rat, which is consistent with the dog having an omnivorous diet during its evolution. It is suggested that during periods of fasting, depletion of urea cycle intermediates in the cat results in some conservation of nitrogen while maintaining urea cycle enzymes at a relatively high level. However, after ingestion of animal protein (and arginine) the urea cycle of cats is capable of rapidly responding to the ammonia load, which rises from the deamination of amino acids. By this method of regulation the cat can respond to short-term fluctuations in protein intake.

UR - http://www.scopus.com/inward/record.url?scp=0021881752&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021881752&partnerID=8YFLogxK

U2 - 10.1093/jn/115.4.524

DO - 10.1093/jn/115.4.524

M3 - Article

VL - 115

SP - 524

EP - 531

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 4

ER -