Nutritional adequacy of goat milk infant formulas for term infants: A double-blind randomised controlled trial

Shao J. Zhou, Thomas Sullivan, Robert A. Gibson, Bo Lönnerdal, Colin G. Prosser, Dianne J. Lowry, Maria Makrides

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The safety and nutritional adequacy of goat milk infant formulas have been questioned. The primary aim of the present study was to compare the growth and nutritional status of infants fed a goat milk infant formula with those of infants fed a typical whey-based cow milk infant formula. The secondary aim was to examine a range of health- and allergy-related outcomes. A double-blind, randomised controlled trial with 200 formula-fed term infants randomly assigned to receive either goat or cow milk formula from 2 weeks to at least 4 months of age was conducted. A cohort of 101 breast-fed infants was included for comparison. Weight, length and head circumference were measured at 2 weeks and 1, 2, 3, 4, 6 and 12 months of age. Nutritional status was assessed from serum albumin, urea, creatinine, Hb, ferritin, and folate and plasma amino acid concentrations at 4 months. Z-scores for weight, length, head circumference and weight for length were not different between the two formula-fed groups. There were differences in the values of some amino acids and blood biomarkers between the formula-fed groups, but the mean values for biomarkers were within the normal reference range. There were no differences in the occurrence of serious adverse events, general health, and incidence of dermatitis or medically diagnosed food allergy. The incidence of parentally reported blood-stained stools was higher in the goat milk formula-fed group, although this was a secondary outcome and its importance is unclear. Goat milk formula provided growth and nutritional outcomes in infants that did not differ from those provided by a standard whey-based cow milk formula.

Original languageEnglish (US)
Pages (from-to)1641-1651
Number of pages11
JournalBritish Journal of Nutrition
Volume111
Issue number9
DOIs
StatePublished - May 14 2014

Fingerprint

Infant Formula
Goats
Milk
Randomized Controlled Trials
Nutritional Status
Weights and Measures
Reference Values
Biomarkers
Head
Amino Acids
Food Hypersensitivity
Incidence
Health
Dermatitis
Ferritins
Growth
Folic Acid
Serum Albumin
Urea
Creatinine

Keywords

  • Breast-feeding
  • Formulas
  • Goat milk
  • Growth
  • Infants

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Zhou, S. J., Sullivan, T., Gibson, R. A., Lönnerdal, B., Prosser, C. G., Lowry, D. J., & Makrides, M. (2014). Nutritional adequacy of goat milk infant formulas for term infants: A double-blind randomised controlled trial. British Journal of Nutrition, 111(9), 1641-1651. https://doi.org/10.1017/S0007114513004212

Nutritional adequacy of goat milk infant formulas for term infants : A double-blind randomised controlled trial. / Zhou, Shao J.; Sullivan, Thomas; Gibson, Robert A.; Lönnerdal, Bo; Prosser, Colin G.; Lowry, Dianne J.; Makrides, Maria.

In: British Journal of Nutrition, Vol. 111, No. 9, 14.05.2014, p. 1641-1651.

Research output: Contribution to journalArticle

Zhou, SJ, Sullivan, T, Gibson, RA, Lönnerdal, B, Prosser, CG, Lowry, DJ & Makrides, M 2014, 'Nutritional adequacy of goat milk infant formulas for term infants: A double-blind randomised controlled trial', British Journal of Nutrition, vol. 111, no. 9, pp. 1641-1651. https://doi.org/10.1017/S0007114513004212
Zhou, Shao J. ; Sullivan, Thomas ; Gibson, Robert A. ; Lönnerdal, Bo ; Prosser, Colin G. ; Lowry, Dianne J. ; Makrides, Maria. / Nutritional adequacy of goat milk infant formulas for term infants : A double-blind randomised controlled trial. In: British Journal of Nutrition. 2014 ; Vol. 111, No. 9. pp. 1641-1651.
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