Nutrition, geoepidemiology, and autoimmunity

Carlo Selmi, Koichi Tsuneyama

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

As well represented by the impaired immune function of malnourished individuals encountered in developing countries and the incidence of specific diseases following local nutrient deficiencies, nutrition and immunity have been linked to each other for centuries while the specific connection between dietary factors and autoimmunity onset or modulation is a more recent acquisition. Autoimmune diseases manifest limited prevalence rates in developing countries while numerous immunity-related claims have been proposed in the field of functional foods. Nevertheless, over the past years multiple lines of evidence have supported a major role for specific dietary factors (including vitamin D, vitamin A, selenium, zinc, omega-3 fatty acids, probiotics, and flavanols) in determining the immune responses involved in infections, allergies, and autoimmune diseases. Interestingly, the link between nutrition and autoimmunity may well contribute to the geoepidemiology observed for numerous conditions. In general terms, most data that will be discussed herein were obtained in experimental or animal models while human data from real-life clinical settings or randomized clinical trials remain largely unsatisfactory. Our current knowledge on the beneficial impact of nutrition on autoimmunity prompts us to encourage the search for evidence-based nutrition to support the everyday diet choices of patients.

Original languageEnglish (US)
JournalAutoimmunity Reviews
Volume9
Issue number5
DOIs
StatePublished - Mar 2010
Externally publishedYes

Fingerprint

Autoimmunity
Developing Countries
Autoimmune Diseases
Immunity
Functional Food
Omega-3 Fatty Acids
Probiotics
Selenium
Vitamin A
Vitamin D
Zinc
Hypersensitivity
Randomized Controlled Trials
Animal Models
Diet
Food
Incidence
Infection

Keywords

  • Diet
  • Geoepidemiology
  • Micronutrients
  • Tolerance breakdown

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Nutrition, geoepidemiology, and autoimmunity. / Selmi, Carlo; Tsuneyama, Koichi.

In: Autoimmunity Reviews, Vol. 9, No. 5, 03.2010.

Research output: Contribution to journalArticle

Selmi, Carlo ; Tsuneyama, Koichi. / Nutrition, geoepidemiology, and autoimmunity. In: Autoimmunity Reviews. 2010 ; Vol. 9, No. 5.
@article{9d01ec1fd4f94b0ba8dc082865231408,
title = "Nutrition, geoepidemiology, and autoimmunity",
abstract = "As well represented by the impaired immune function of malnourished individuals encountered in developing countries and the incidence of specific diseases following local nutrient deficiencies, nutrition and immunity have been linked to each other for centuries while the specific connection between dietary factors and autoimmunity onset or modulation is a more recent acquisition. Autoimmune diseases manifest limited prevalence rates in developing countries while numerous immunity-related claims have been proposed in the field of functional foods. Nevertheless, over the past years multiple lines of evidence have supported a major role for specific dietary factors (including vitamin D, vitamin A, selenium, zinc, omega-3 fatty acids, probiotics, and flavanols) in determining the immune responses involved in infections, allergies, and autoimmune diseases. Interestingly, the link between nutrition and autoimmunity may well contribute to the geoepidemiology observed for numerous conditions. In general terms, most data that will be discussed herein were obtained in experimental or animal models while human data from real-life clinical settings or randomized clinical trials remain largely unsatisfactory. Our current knowledge on the beneficial impact of nutrition on autoimmunity prompts us to encourage the search for evidence-based nutrition to support the everyday diet choices of patients.",
keywords = "Diet, Geoepidemiology, Micronutrients, Tolerance breakdown",
author = "Carlo Selmi and Koichi Tsuneyama",
year = "2010",
month = "3",
doi = "10.1016/j.autrev.2009.12.001",
language = "English (US)",
volume = "9",
journal = "Autoimmunity Reviews",
issn = "1568-9972",
publisher = "Elsevier",
number = "5",

}

TY - JOUR

T1 - Nutrition, geoepidemiology, and autoimmunity

AU - Selmi, Carlo

AU - Tsuneyama, Koichi

PY - 2010/3

Y1 - 2010/3

N2 - As well represented by the impaired immune function of malnourished individuals encountered in developing countries and the incidence of specific diseases following local nutrient deficiencies, nutrition and immunity have been linked to each other for centuries while the specific connection between dietary factors and autoimmunity onset or modulation is a more recent acquisition. Autoimmune diseases manifest limited prevalence rates in developing countries while numerous immunity-related claims have been proposed in the field of functional foods. Nevertheless, over the past years multiple lines of evidence have supported a major role for specific dietary factors (including vitamin D, vitamin A, selenium, zinc, omega-3 fatty acids, probiotics, and flavanols) in determining the immune responses involved in infections, allergies, and autoimmune diseases. Interestingly, the link between nutrition and autoimmunity may well contribute to the geoepidemiology observed for numerous conditions. In general terms, most data that will be discussed herein were obtained in experimental or animal models while human data from real-life clinical settings or randomized clinical trials remain largely unsatisfactory. Our current knowledge on the beneficial impact of nutrition on autoimmunity prompts us to encourage the search for evidence-based nutrition to support the everyday diet choices of patients.

AB - As well represented by the impaired immune function of malnourished individuals encountered in developing countries and the incidence of specific diseases following local nutrient deficiencies, nutrition and immunity have been linked to each other for centuries while the specific connection between dietary factors and autoimmunity onset or modulation is a more recent acquisition. Autoimmune diseases manifest limited prevalence rates in developing countries while numerous immunity-related claims have been proposed in the field of functional foods. Nevertheless, over the past years multiple lines of evidence have supported a major role for specific dietary factors (including vitamin D, vitamin A, selenium, zinc, omega-3 fatty acids, probiotics, and flavanols) in determining the immune responses involved in infections, allergies, and autoimmune diseases. Interestingly, the link between nutrition and autoimmunity may well contribute to the geoepidemiology observed for numerous conditions. In general terms, most data that will be discussed herein were obtained in experimental or animal models while human data from real-life clinical settings or randomized clinical trials remain largely unsatisfactory. Our current knowledge on the beneficial impact of nutrition on autoimmunity prompts us to encourage the search for evidence-based nutrition to support the everyday diet choices of patients.

KW - Diet

KW - Geoepidemiology

KW - Micronutrients

KW - Tolerance breakdown

UR - http://www.scopus.com/inward/record.url?scp=77649238845&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77649238845&partnerID=8YFLogxK

U2 - 10.1016/j.autrev.2009.12.001

DO - 10.1016/j.autrev.2009.12.001

M3 - Article

C2 - 19969106

AN - SCOPUS:77649238845

VL - 9

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

SN - 1568-9972

IS - 5

ER -