Abstract
It is well recognized that lipid in the intestine is a potent inhibitor of gastric secretomotor function. Progress has been made in the identification of the 'sensor' for lipid in the intestinal wall. Long-chain free fatty acids are the stimulus both for release of CCK and for the production of functional effects. Long-chain triglyceride requires chylomicron formation for absorption, and there is strong evidence that the postabsorptive products of long-chain triglyceride absorption, including chylomicrons and apolipoproteins, are involved in sensory transduction in the intestinal wall.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Physiology - Gastrointestinal and Liver Physiology |
| Volume | 277 |
| Issue number | 4 40-4 |
| State | Published - 1999 |
| Externally published | Yes |
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Keywords
- Cholecystokinin A receptors
- Chylomicrons
- Long-chain fatty acids
- Vagal afferents
ASJC Scopus subject areas
- Gastroenterology
- Physiology
- Physiology (medical)
Cite this
Nutrient Tasting and Signaling Mechanisms in the Gut. I. Sensing of lipid by the intestinal mucosa. / Raybould, Helen E.
In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 277, No. 4 40-4, 1999.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nutrient Tasting and Signaling Mechanisms in the Gut. I. Sensing of lipid by the intestinal mucosa
AU - Raybould, Helen E
PY - 1999
Y1 - 1999
N2 - It is well recognized that lipid in the intestine is a potent inhibitor of gastric secretomotor function. Progress has been made in the identification of the 'sensor' for lipid in the intestinal wall. Long-chain free fatty acids are the stimulus both for release of CCK and for the production of functional effects. Long-chain triglyceride requires chylomicron formation for absorption, and there is strong evidence that the postabsorptive products of long-chain triglyceride absorption, including chylomicrons and apolipoproteins, are involved in sensory transduction in the intestinal wall.
AB - It is well recognized that lipid in the intestine is a potent inhibitor of gastric secretomotor function. Progress has been made in the identification of the 'sensor' for lipid in the intestinal wall. Long-chain free fatty acids are the stimulus both for release of CCK and for the production of functional effects. Long-chain triglyceride requires chylomicron formation for absorption, and there is strong evidence that the postabsorptive products of long-chain triglyceride absorption, including chylomicrons and apolipoproteins, are involved in sensory transduction in the intestinal wall.
KW - Cholecystokinin A receptors
KW - Chylomicrons
KW - Long-chain fatty acids
KW - Vagal afferents
UR - http://www.scopus.com/inward/record.url?scp=0032741937&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032741937&partnerID=8YFLogxK
M3 - Article
C2 - 10516140
AN - SCOPUS:0032741937
VL - 277
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
SN - 1931-857X
IS - 4 40-4
ER -