Nucleus tractus solitarius lesions block the behavioral actions of cholecystokinin

Jacqueline Crawley, J. S. Schwaber

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Cholecystokinin (CCK) has been implicated as a signal for the syndrome of satiety in a variety of species. Several lines of evidence point to a peripheral site of action for the behavioral effects of CCK. Peripheral CCK receptors appear to activate a gut-brain pathway involving the sensory fibers of the vagus nerve. To investigate the central anatomical substrate of this visceral-behavioral control system, the terminal regions of the sensory tract of the vagus were lesioned. Radiofrequency lesions of the nucleus tractus solitarius abolished the effects of acute doses of CCK on exploratory behaviors. Sham lesions had no effect on baseline exploratory behaviors and did not influence the ability of CCK to decrease spontaneous exploratory behaviors. These findings delineate the first central site along the ascending sensory pathway which appears to mediate the satiety-related behavioral effects of CCK.

Original languageEnglish (US)
Pages (from-to)743-747
Number of pages5
JournalPeptides
Volume4
Issue number5
DOIs
StatePublished - 1983
Externally publishedYes

Fingerprint

Solitary Nucleus
Cholecystokinin
Exploratory Behavior
Cholecystokinin Receptors
Aptitude
Vagus Nerve
Brain
Control systems
Fibers
Substrates

Keywords

  • Cholecystokinin (CCK)
  • Nucleus tractus solitarius lesions
  • Satiety

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Nucleus tractus solitarius lesions block the behavioral actions of cholecystokinin. / Crawley, Jacqueline; Schwaber, J. S.

In: Peptides, Vol. 4, No. 5, 1983, p. 743-747.

Research output: Contribution to journalArticle

@article{959860960225485abf4302636a3d9a6b,
title = "Nucleus tractus solitarius lesions block the behavioral actions of cholecystokinin",
abstract = "Cholecystokinin (CCK) has been implicated as a signal for the syndrome of satiety in a variety of species. Several lines of evidence point to a peripheral site of action for the behavioral effects of CCK. Peripheral CCK receptors appear to activate a gut-brain pathway involving the sensory fibers of the vagus nerve. To investigate the central anatomical substrate of this visceral-behavioral control system, the terminal regions of the sensory tract of the vagus were lesioned. Radiofrequency lesions of the nucleus tractus solitarius abolished the effects of acute doses of CCK on exploratory behaviors. Sham lesions had no effect on baseline exploratory behaviors and did not influence the ability of CCK to decrease spontaneous exploratory behaviors. These findings delineate the first central site along the ascending sensory pathway which appears to mediate the satiety-related behavioral effects of CCK.",
keywords = "Cholecystokinin (CCK), Nucleus tractus solitarius lesions, Satiety",
author = "Jacqueline Crawley and Schwaber, {J. S.}",
year = "1983",
doi = "10.1016/0196-9781(83)90030-X",
language = "English (US)",
volume = "4",
pages = "743--747",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Nucleus tractus solitarius lesions block the behavioral actions of cholecystokinin

AU - Crawley, Jacqueline

AU - Schwaber, J. S.

PY - 1983

Y1 - 1983

N2 - Cholecystokinin (CCK) has been implicated as a signal for the syndrome of satiety in a variety of species. Several lines of evidence point to a peripheral site of action for the behavioral effects of CCK. Peripheral CCK receptors appear to activate a gut-brain pathway involving the sensory fibers of the vagus nerve. To investigate the central anatomical substrate of this visceral-behavioral control system, the terminal regions of the sensory tract of the vagus were lesioned. Radiofrequency lesions of the nucleus tractus solitarius abolished the effects of acute doses of CCK on exploratory behaviors. Sham lesions had no effect on baseline exploratory behaviors and did not influence the ability of CCK to decrease spontaneous exploratory behaviors. These findings delineate the first central site along the ascending sensory pathway which appears to mediate the satiety-related behavioral effects of CCK.

AB - Cholecystokinin (CCK) has been implicated as a signal for the syndrome of satiety in a variety of species. Several lines of evidence point to a peripheral site of action for the behavioral effects of CCK. Peripheral CCK receptors appear to activate a gut-brain pathway involving the sensory fibers of the vagus nerve. To investigate the central anatomical substrate of this visceral-behavioral control system, the terminal regions of the sensory tract of the vagus were lesioned. Radiofrequency lesions of the nucleus tractus solitarius abolished the effects of acute doses of CCK on exploratory behaviors. Sham lesions had no effect on baseline exploratory behaviors and did not influence the ability of CCK to decrease spontaneous exploratory behaviors. These findings delineate the first central site along the ascending sensory pathway which appears to mediate the satiety-related behavioral effects of CCK.

KW - Cholecystokinin (CCK)

KW - Nucleus tractus solitarius lesions

KW - Satiety

UR - http://www.scopus.com/inward/record.url?scp=0021088537&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021088537&partnerID=8YFLogxK

U2 - 10.1016/0196-9781(83)90030-X

DO - 10.1016/0196-9781(83)90030-X

M3 - Article

C2 - 6318204

AN - SCOPUS:0021088537

VL - 4

SP - 743

EP - 747

JO - Peptides

JF - Peptides

SN - 0196-9781

IS - 5

ER -