Nucleus tractus solitarius lesions block the behavioral actions of cholecystokinin

Jacqueline Crawley, J. S. Schwaber

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Cholecystokinin (CCK) has been implicated as a signal for the syndrome of satiety in a variety of species. Several lines of evidence point to a peripheral site of action for the behavioral effects of CCK. Peripheral CCK receptors appear to activate a gut-brain pathway involving the sensory fibers of the vagus nerve. To investigate the central anatomical substrate of this visceral-behavioral control system, the terminal regions of the sensory tract of the vagus were lesioned. Radiofrequency lesions of the nucleus tractus solitarius abolished the effects of acute doses of CCK on exploratory behaviors. Sham lesions had no effect on baseline exploratory behaviors and did not influence the ability of CCK to decrease spontaneous exploratory behaviors. These findings delineate the first central site along the ascending sensory pathway which appears to mediate the satiety-related behavioral effects of CCK.

Original languageEnglish (US)
Pages (from-to)743-747
Number of pages5
Issue number5
StatePublished - 1983
Externally publishedYes


  • Cholecystokinin (CCK)
  • Nucleus tractus solitarius lesions
  • Satiety

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience


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