Nucleotide sequence of SRV-1, a type D simian acquired immune deficiency syndrome retrovirus

Michael D. Power, Preston A. Marx, Martin L. Bryant, Murray B. Gardner, Philip J. Barr, Paul A Luciw

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Simian acquired immune deficiency syndrome (SAIDS) in the macaque genus of monkeys at the California Primate Research Center is apparently caused by infection by a type D retrovirus. The complete nucleotide sequence (8173 base pairs) of a molecular clone of the prototype SAIDS virus isolate, SRV-1, reveals a typical retrovirus structure with long terminal repeats (346 base pairs) and open reading frames for the gag (663 codons), pol (867 codons), and env (605 codons) genes. SRV-1 also has a separate open reading frame of 314 codons between the gag and pol genes that defines the viral protease gene (prt) and a short open reading frame of unknown significance downstream from the env gene. The SRV-1 protease region shows a high degree of homology to its counterpart in the hamster intracisternal A-type particle genome; both these protease genes are about twice as long as the analogous region of other retroviruses. SRV-1 has no notable similarity in either genetic organization or sequence to the human AIDS retroviruses.

Original languageEnglish (US)
Pages (from-to)1567-1572
Number of pages6
JournalScience
Volume231
Issue number4745
StatePublished - 1986
Externally publishedYes

Fingerprint

Simian Acquired Immunodeficiency Syndrome
Mason-Pfizer monkey virus
Retroviridae
Codon
Open Reading Frames
Peptide Hydrolases
Base Pairing
Betaretrovirus
pol Genes
gag Genes
env Genes
Viral Genes
Terminal Repeat Sequences
Macaca
Cricetinae
Primates
Genes
Haplorhini
Acquired Immunodeficiency Syndrome
Clone Cells

ASJC Scopus subject areas

  • General

Cite this

Power, M. D., Marx, P. A., Bryant, M. L., Gardner, M. B., Barr, P. J., & Luciw, P. A. (1986). Nucleotide sequence of SRV-1, a type D simian acquired immune deficiency syndrome retrovirus. Science, 231(4745), 1567-1572.

Nucleotide sequence of SRV-1, a type D simian acquired immune deficiency syndrome retrovirus. / Power, Michael D.; Marx, Preston A.; Bryant, Martin L.; Gardner, Murray B.; Barr, Philip J.; Luciw, Paul A.

In: Science, Vol. 231, No. 4745, 1986, p. 1567-1572.

Research output: Contribution to journalArticle

Power, MD, Marx, PA, Bryant, ML, Gardner, MB, Barr, PJ & Luciw, PA 1986, 'Nucleotide sequence of SRV-1, a type D simian acquired immune deficiency syndrome retrovirus', Science, vol. 231, no. 4745, pp. 1567-1572.
Power MD, Marx PA, Bryant ML, Gardner MB, Barr PJ, Luciw PA. Nucleotide sequence of SRV-1, a type D simian acquired immune deficiency syndrome retrovirus. Science. 1986;231(4745):1567-1572.
Power, Michael D. ; Marx, Preston A. ; Bryant, Martin L. ; Gardner, Murray B. ; Barr, Philip J. ; Luciw, Paul A. / Nucleotide sequence of SRV-1, a type D simian acquired immune deficiency syndrome retrovirus. In: Science. 1986 ; Vol. 231, No. 4745. pp. 1567-1572.
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abstract = "Simian acquired immune deficiency syndrome (SAIDS) in the macaque genus of monkeys at the California Primate Research Center is apparently caused by infection by a type D retrovirus. The complete nucleotide sequence (8173 base pairs) of a molecular clone of the prototype SAIDS virus isolate, SRV-1, reveals a typical retrovirus structure with long terminal repeats (346 base pairs) and open reading frames for the gag (663 codons), pol (867 codons), and env (605 codons) genes. SRV-1 also has a separate open reading frame of 314 codons between the gag and pol genes that defines the viral protease gene (prt) and a short open reading frame of unknown significance downstream from the env gene. The SRV-1 protease region shows a high degree of homology to its counterpart in the hamster intracisternal A-type particle genome; both these protease genes are about twice as long as the analogous region of other retroviruses. SRV-1 has no notable similarity in either genetic organization or sequence to the human AIDS retroviruses.",
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N2 - Simian acquired immune deficiency syndrome (SAIDS) in the macaque genus of monkeys at the California Primate Research Center is apparently caused by infection by a type D retrovirus. The complete nucleotide sequence (8173 base pairs) of a molecular clone of the prototype SAIDS virus isolate, SRV-1, reveals a typical retrovirus structure with long terminal repeats (346 base pairs) and open reading frames for the gag (663 codons), pol (867 codons), and env (605 codons) genes. SRV-1 also has a separate open reading frame of 314 codons between the gag and pol genes that defines the viral protease gene (prt) and a short open reading frame of unknown significance downstream from the env gene. The SRV-1 protease region shows a high degree of homology to its counterpart in the hamster intracisternal A-type particle genome; both these protease genes are about twice as long as the analogous region of other retroviruses. SRV-1 has no notable similarity in either genetic organization or sequence to the human AIDS retroviruses.

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