Nuclear receptors and inflammatory diseases

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

It is well known that the steroid hormone glucocorticoid and its nuclear receptor regulate the inflammatory process, a crucial component in the pathophysiological process related to human diseases that include atherosclerosis, obesity and type II diabetes, inflammatory bowel disease, Alzheimer's disease, multiple sclerosis, and liver tumors. Growing evidence demonstrates that orphan and adopted orphan nuclear receptors, such as peroxisome proliferator-activated receptors, liver x receptors, the farnesoid x receptor, NR4As, retinoid x receptors, and the pregnane x receptor, regulate the inflammatory and metabolic profiles in a ligand-dependent or -independent manner in human and animal models. This review summarizes the regulatory roles of these nuclear receptors in the inflammatory process and the underlying mechanisms.

Original languageEnglish (US)
Pages (from-to)496-506
Number of pages11
JournalExperimental Biology and Medicine
Volume233
Issue number5
DOIs
StatePublished - May 2008
Externally publishedYes

Fingerprint

Cytoplasmic and Nuclear Receptors
Orphan Nuclear Receptors
Pregnanes
Liver
Peroxisome Proliferator-Activated Receptors
Orphaned Children
Metabolome
Retinoids
Steroid hormones
Inflammatory Bowel Diseases
Type 2 Diabetes Mellitus
Glucocorticoids
Multiple Sclerosis
Atherosclerosis
Alzheimer Disease
Animal Models
Obesity
Steroids
Hormones
Medical problems

Keywords

  • Farnesoid x receptor
  • Inflammation
  • Liver
  • Liver x receptors
  • NR4As
  • Nuclear receptor
  • Peroxisome proliferator-activated receptors
  • Retinoid x receptors
  • Steroid xenobiotic receptor/pregnane x receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nuclear receptors and inflammatory diseases. / Wang, Kun; Wan, Yu-Jui Yvonne.

In: Experimental Biology and Medicine, Vol. 233, No. 5, 05.2008, p. 496-506.

Research output: Contribution to journalArticle

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