Nuclear magnetic resonance analysis of solution conformations in C4-V3 hybrid peptides derived from human immunodeficiency virus (HIV) type 1 gp120: Relation to specificity of peptide-induced anti-HIV neutralizing antibodies

Hai M. Vu, David Myers, Robert De Lorimier, Thomas J. Matthews, M. Anthony Moody, Craig Heinly, Jose V Torres, Barton F. Haynes, Leonard Spicer

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Immunogenic peptides containing epitopes of the gp120 C4 and V3 regions from human immunodeficiency virus strains MN and EV91 have been studied by nuclear magnetic resonance and molecular modeling and used as immunogens in rhesus monkeys. The results, combined with those for other peptides, suggest a correlation between solution conformation and immunologic cross-reactivity.

Original languageEnglish (US)
Pages (from-to)746-750
Number of pages5
JournalJournal of Virology
Volume73
Issue number1
StatePublished - 1999

ASJC Scopus subject areas

  • Immunology

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