Nuclear magnetic resonance analysis of solution conformations in C4-V3 hybrid peptides derived from human immunodeficiency virus (HIV) type 1 gp120

Relation to specificity of peptide-induced anti-HIV neutralizing antibodies

Hai M. Vu, David Myers, Robert De Lorimier, Thomas J. Matthews, M. Anthony Moody, Craig Heinly, Jose V Torres, Barton F. Haynes, Leonard Spicer

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Immunogenic peptides containing epitopes of the gp120 C4 and V3 regions from human immunodeficiency virus strains MN and EV91 have been studied by nuclear magnetic resonance and molecular modeling and used as immunogens in rhesus monkeys. The results, combined with those for other peptides, suggest a correlation between solution conformation and immunologic cross-reactivity.

Original languageEnglish (US)
Pages (from-to)746-750
Number of pages5
JournalJournal of Virology
Volume73
Issue number1
StatePublished - 1999

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Human immunodeficiency virus
Human immunodeficiency virus 1
Neutralizing Antibodies
neutralizing antibodies
HIV-1
nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
HIV
peptides
Peptides
Macaca mulatta
cross reaction
epitopes
Epitopes
antigens

ASJC Scopus subject areas

  • Immunology

Cite this

Nuclear magnetic resonance analysis of solution conformations in C4-V3 hybrid peptides derived from human immunodeficiency virus (HIV) type 1 gp120 : Relation to specificity of peptide-induced anti-HIV neutralizing antibodies. / Vu, Hai M.; Myers, David; De Lorimier, Robert; Matthews, Thomas J.; Anthony Moody, M.; Heinly, Craig; Torres, Jose V; Haynes, Barton F.; Spicer, Leonard.

In: Journal of Virology, Vol. 73, No. 1, 1999, p. 746-750.

Research output: Contribution to journalArticle

Vu, Hai M. ; Myers, David ; De Lorimier, Robert ; Matthews, Thomas J. ; Anthony Moody, M. ; Heinly, Craig ; Torres, Jose V ; Haynes, Barton F. ; Spicer, Leonard. / Nuclear magnetic resonance analysis of solution conformations in C4-V3 hybrid peptides derived from human immunodeficiency virus (HIV) type 1 gp120 : Relation to specificity of peptide-induced anti-HIV neutralizing antibodies. In: Journal of Virology. 1999 ; Vol. 73, No. 1. pp. 746-750.
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