Nuclear calcium in cardiac myocytes

Senka Ljubojevic, Donald M Bers

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Calcium (Ca2+) is a universal second messenger involved in the regulation of various cellular processes, including electrical signaling, contraction, secretion, memory, gene transcription, and cell death. In heart, Ca2+ governs cardiomyocyte contraction, is central in electrophysiological properties, and controls major signaling pathway implicated in gene transcription. How cardiomyocytes decode Ca2+ signal to regulate gene expression without interfering with, or being controlled by, "contractile" Ca2+ that floods the entire cytosol during each heartbeat is still elusive. In this review, we summarize recent findings on nuclear Ca2+ regulation and its downstream signaling in cardiomyocytes. We will address difficulties in reliable quantification of nuclear Ca2+ fluxes and discuss its role in the development and progression of cardiac hypertrophy and heart failure. We also point out key open questions to stimulate future work.

Original languageEnglish (US)
Pages (from-to)211-217
Number of pages7
JournalJournal of Cardiovascular Pharmacology
Volume65
Issue number3
StatePublished - 2015

Keywords

  • calcium signaling
  • cardiac remodeling
  • cardiomyocyte
  • nuclear calcium

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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