Nuclear and spindle positioning during oocyte meiosis

Amy S. Fabritius; Marina L. Ellefson; Francis J. McNally

doi:10.1016/j.ceb.2010.07.008

Nuclear and spindle positioning during oocyte meiosis

Amy S. Fabritius, Marina L. Ellefson, Francis J. McNally

Molecular and Cellular Biology

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Female meiosis is unique in that an asymmetrically positioned meiotic spindle expels chromosomes into tiny, non-developing polar bodies. The extrusion of chromosomes into polar bodies is always mediated by meiotic spindles that are attached to the oocyte cortex by one pole. The asymmetric, cortical positioning of the oocyte meiotic spindle preserves the volume and contents of the oocyte. Recent work in C. elegans and mouse has provided mechanistic details of spindle positioning in oocytes.

Original language	English (US)
Pages (from-to)	78-84
Number of pages	7
Journal	Current Opinion in Cell Biology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.ceb.2010.07.008
State	Published - Feb 2011

ASJC Scopus subject areas

Cell Biology

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10.1016/j.ceb.2010.07.008

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abstract = "Female meiosis is unique in that an asymmetrically positioned meiotic spindle expels chromosomes into tiny, non-developing polar bodies. The extrusion of chromosomes into polar bodies is always mediated by meiotic spindles that are attached to the oocyte cortex by one pole. The asymmetric, cortical positioning of the oocyte meiotic spindle preserves the volume and contents of the oocyte. Recent work in C. elegans and mouse has provided mechanistic details of spindle positioning in oocytes.",

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AU - Ellefson, Marina L.

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AB - Female meiosis is unique in that an asymmetrically positioned meiotic spindle expels chromosomes into tiny, non-developing polar bodies. The extrusion of chromosomes into polar bodies is always mediated by meiotic spindles that are attached to the oocyte cortex by one pole. The asymmetric, cortical positioning of the oocyte meiotic spindle preserves the volume and contents of the oocyte. Recent work in C. elegans and mouse has provided mechanistic details of spindle positioning in oocytes.

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Nuclear and spindle positioning during oocyte meiosis

Abstract

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