Nuclear and spindle positioning during oocyte meiosis

Amy S. Fabritius, Marina L. Ellefson, Francis J. McNally

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Female meiosis is unique in that an asymmetrically positioned meiotic spindle expels chromosomes into tiny, non-developing polar bodies. The extrusion of chromosomes into polar bodies is always mediated by meiotic spindles that are attached to the oocyte cortex by one pole. The asymmetric, cortical positioning of the oocyte meiotic spindle preserves the volume and contents of the oocyte. Recent work in C. elegans and mouse has provided mechanistic details of spindle positioning in oocytes.

Original languageEnglish (US)
Pages (from-to)78-84
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume23
Issue number1
DOIs
StatePublished - Feb 2011

ASJC Scopus subject areas

  • Cell Biology

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