Abstract
"Chemical equation presented" Nucleoside analogs that project substituents Into the minor groove when incorporated into duplex RNA perturb the binding of proteins and can affect base pairing specificity. The synthesis of 2-amlnopurine ribonucleoside analogs and their phosphoramldites, their incorporation into duplex RNA, their postsynthetic modification via Cu-catalyzed azide-alkyne cycloaddition (CuAAC), and their effect on duplex stability and base pairing specificity are described.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1044-1047 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 12 |
| Issue number | 5 |
| DOIs | |
| State | Published - Mar 5 2010 |
ASJC Scopus subject areas
- Organic Chemistry
- Physical and Theoretical Chemistry
- Biochemistry
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Cite this
Peacock, H., Maydanovych, O., & Beal, P. A. (2010). N2-Modified 2-aminopurine ribonucleosides as minor-groove-modulating adenosine replacements in duplex RNA. Organic Letters, 12(5), 1044-1047. https://doi.org/10.1021/ol100019r