Now you see me, now you don't: the interaction of Salmonella with innate immune receptors

A. Marijke Keestra-Gounder, Renee M Tsolis, Andreas J Baumler

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

Salmonella enterica serovars are associated with an estimated 1 million deaths annually and are also useful model organisms for investigating the mechanisms of host-bacterium interactions. The insights gained from studies on non-typhoidal Salmonella (NTS) serovars have provided a fascinating overview of the mechanisms by which the innate immune system detects and responds to bacterial pathogens. However, specific virulence factors and changes in virulence gene regulation in S. enterica subsp. enterica serovar Typhi alter the innate immune responses to this pathogen. In this Review, we compare and contrast the interactions of S. Typhi and NTS serovars with host innate immune receptors and discuss why the disease manifestations associated with S. Typhi infection differ considerably from those associated with the closely related NTS serovars.

Original languageEnglish (US)
Pages (from-to)206-216
Number of pages11
JournalNature Reviews Microbiology
Volume13
Issue number4
DOIs
StatePublished - Mar 16 2015

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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