Novel use of endoscopically placed fiducial markers for targeted radiation therapy of colonic lymphomas

Grigoriy E. Gurvits; Joseph Marsano; Boris Kobrinsky; Samuel Shin; Nicholas Sanfilippo; Dmitri Volkov

Novel use of endoscopically placed fiducial markers for targeted radiation therapy of colonic lymphomas

Grigoriy E. Gurvits, Joseph Marsano, Boris Kobrinsky, Samuel Shin, Nicholas Sanfilippo, Dmitri Volkov

Research output: Contribution to journal › Article › peer-review

Abstract

Non-Hodgkin’s lymphomas (NHL) are an important variety of gastrointestinal tumors with increasing incidence and prevalence. Traditional management of NHL with chemotherapy is challenging and expanding evidence points to significant tumor response to radiation therapy (RT). However, there exists a wide range of radiation-related toxicities. Optimization of exact tumor marking coupled with minimization of the radius of radiation delivery is essential to increase patient’s tolerance and decrease side effects of the treatment. We report our experience with mantle cell lymphoma of the colon treated with precision RT after endoscopic placement of resolution clips in a “shooting target” fashion in a patient who failed conventional chemotherapy. Fourteen months after completion of RT, the patient remains in complete remission.

Original language	English (US)
Pages (from-to)	421-423
Number of pages	3
Journal	Annals of Gastroenterology
Volume	27
Issue number	4
State	Published - 2014
Externally published	Yes

Keywords

Colonoscopy
Endoscopy
Gastrointestinal cancer
Mantle cell lymphoma
Radiation therapy

ASJC Scopus subject areas

Gastroenterology

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title = "Novel use of endoscopically placed fiducial markers for targeted radiation therapy of colonic lymphomas",

abstract = "Non-Hodgkin{\textquoteright}s lymphomas (NHL) are an important variety of gastrointestinal tumors with increasing incidence and prevalence. Traditional management of NHL with chemotherapy is challenging and expanding evidence points to significant tumor response to radiation therapy (RT). However, there exists a wide range of radiation-related toxicities. Optimization of exact tumor marking coupled with minimization of the radius of radiation delivery is essential to increase patient{\textquoteright}s tolerance and decrease side effects of the treatment. We report our experience with mantle cell lymphoma of the colon treated with precision RT after endoscopic placement of resolution clips in a “shooting target” fashion in a patient who failed conventional chemotherapy. Fourteen months after completion of RT, the patient remains in complete remission.",

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T1 - Novel use of endoscopically placed fiducial markers for targeted radiation therapy of colonic lymphomas

AU - Gurvits, Grigoriy E.

AU - Marsano, Joseph

AU - Kobrinsky, Boris

AU - Shin, Samuel

AU - Sanfilippo, Nicholas

AU - Volkov, Dmitri

PY - 2014

Y1 - 2014

N2 - Non-Hodgkin’s lymphomas (NHL) are an important variety of gastrointestinal tumors with increasing incidence and prevalence. Traditional management of NHL with chemotherapy is challenging and expanding evidence points to significant tumor response to radiation therapy (RT). However, there exists a wide range of radiation-related toxicities. Optimization of exact tumor marking coupled with minimization of the radius of radiation delivery is essential to increase patient’s tolerance and decrease side effects of the treatment. We report our experience with mantle cell lymphoma of the colon treated with precision RT after endoscopic placement of resolution clips in a “shooting target” fashion in a patient who failed conventional chemotherapy. Fourteen months after completion of RT, the patient remains in complete remission.

AB - Non-Hodgkin’s lymphomas (NHL) are an important variety of gastrointestinal tumors with increasing incidence and prevalence. Traditional management of NHL with chemotherapy is challenging and expanding evidence points to significant tumor response to radiation therapy (RT). However, there exists a wide range of radiation-related toxicities. Optimization of exact tumor marking coupled with minimization of the radius of radiation delivery is essential to increase patient’s tolerance and decrease side effects of the treatment. We report our experience with mantle cell lymphoma of the colon treated with precision RT after endoscopic placement of resolution clips in a “shooting target” fashion in a patient who failed conventional chemotherapy. Fourteen months after completion of RT, the patient remains in complete remission.

KW - Colonoscopy

KW - Endoscopy

KW - Gastrointestinal cancer

KW - Mantle cell lymphoma

KW - Radiation therapy

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