Novel trends in celiac disease

Torsten Matthias, Sandra Neidhöfer, Sascha Pfeiffer, Kai Prager, Sandra Reuter, M. Eric Gershwin

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Celiac disease (CD) is one of the most common food intolerances in developed world. It affects genetically susceptible individuals and has severe consequences if it remains undiagnosed. A disease known for more than a century, it is still the focus for experts from various fields of research and development. Geneticists, pathologists, immunologists, food engineers and dieticians share their knowledge and expertise to improve the conditions of CD patients. With new insights in the pathomechanism of gluten processing and antigen presentation in CD, it was possible to improve the diagnostic antigen mimicking the primary epitope in CD. These celiac neo-epitopes are comprised of a complex of gliadin peptides crosslinked with transglutaminase (tTg). They are an early diagnostic marker for CD which occurs up to 6 months earlier than classical markers known to miss a certain amount of CD patients.

Original languageEnglish (US)
Pages (from-to)121-125
Number of pages5
JournalCellular and Molecular Immunology
Volume8
Issue number2
DOIs
StatePublished - Mar 2011

Keywords

  • celiac disease
  • celiac neo-epitope
  • diagnostic marker
  • gluten
  • tissue transglutaminase

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

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    Matthias, T., Neidhöfer, S., Pfeiffer, S., Prager, K., Reuter, S., & Gershwin, M. E. (2011). Novel trends in celiac disease. Cellular and Molecular Immunology, 8(2), 121-125. https://doi.org/10.1038/cmi.2010.68