Novel techniques to study visceral hypersensitivity in irritable bowel syndrome

Trinh Truong, Bruce D. Naliboff, Lin Chang

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Visceral hypersensitivity has emerged as a key hypothesis in explaining the painful symptoms of irritable bowel syndrome (IBS), and it has been proposed as a "biologic marker" for the condition. Visceral hypersensitivity can be influenced by peripheral and central mechanisms affecting pain perception. The optimal method for its assessment in humans has not been determined. Current techniques include stimulation via the computerized barostat and electrical stimulation, response measures including the lower limb reflex, and brain imaging modalities such as functional MRI and positron emission tomography. It has been shown that IBS patients have decreased sensory thresholds to colonic and rectal balloon distention by barostat. Studies using electrical stimulation and the RIII lower limb reflex have further confirmed enhanced visceral perception in IBS. Evidence from more recent neuroimaging studies suggests that IBS patients have abnormal activation of brain circuits involved in emotional and cognitive modulation of sensory information, resulting in ineffective pain modulation; these circuits may have a pathophysiologic role in enhancing visceral perception. There are few effective pharmacologic treatments that relieve IBS symptoms, and improved understanding of brain-gut interactions and factors relating to enhanced visceral perception may guide us in developing more efficacious treatments.

Original languageEnglish (US)
Pages (from-to)369-378
Number of pages10
JournalCurrent Gastroenterology Reports
Volume10
Issue number4
DOIs
StatePublished - Dec 1 2008
Externally publishedYes

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Irritable Bowel Syndrome
Hypersensitivity
proctolin
Neuroimaging
Electric Stimulation
Reflex
Lower Extremity
Sensory Thresholds
Pain Perception
Brain
Positron-Emission Tomography
Biomarkers
Magnetic Resonance Imaging
Pain
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Novel techniques to study visceral hypersensitivity in irritable bowel syndrome. / Truong, Trinh; Naliboff, Bruce D.; Chang, Lin.

In: Current Gastroenterology Reports, Vol. 10, No. 4, 01.12.2008, p. 369-378.

Research output: Contribution to journalReview article

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