Novel strategies for immuno-oncology breakthroughs with cell therapy

Hongtao Liu, Chongxian Pan, Wenru Song, Delong Liu, Zihai Li, Lei Zheng

Research output: Contribution to journalReview articlepeer-review

Abstract

Cell therapy has evolved rapidly in the past several years with more than 250 clinical trials ongoing around the world. While more indications of cellular therapy with chimeric antigen receptor – engineered T cells (CAR-T) are approved for hematologic malignancies, new concepts and strategies of cellular therapy for solid tumors are emerging and are discussed. These developments include better selections of targets by shifting from tumor-associated antigens to personalized tumor-specific neoantigens, an enhancement of T cell trafficking by breaking the stromal barriers, and a rejuvenation of exhausted T cells by targeting immunosuppressive mechanisms in the tumor microenvironment (TME). Despite significant remaining challenges, we believe that cell therapy will once again lead and revolutionize cancer immunotherapy before long because of the maturation of technologies in T cell engineering, target selection and T cell delivery. This review highlighted the recent progresses reported at the 2020 China Immuno-Oncology Workshop co-organized by the Chinese American Hematologist and Oncologist Network (CAHON), the China National Medical Product Administration (NMPA), and Tsinghua University.

Original languageEnglish (US)
Article number62
JournalBiomarker Research
Volume9
Issue number1
DOIs
StatePublished - Dec 2021
Externally publishedYes

Keywords

  • CAR-T
  • Cellular Therapy
  • Neoantigen
  • TCR-T
  • TME

ASJC Scopus subject areas

  • Molecular Medicine
  • Clinical Biochemistry
  • Biochemistry, medical

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