Abstract
The in vitro incubation of murine keratinocytes in the presence of 1α,25-dihydroxyvitamin D3 enhanced the rapid hydrolysis of the prelabeled keratinocyte polyphosphoinositides (polyPtdIns) when compared to untreated cells. The rapid hydrolysis of the polyPtdIns and the release of the inositol phosphosphates (particularly InsP3 and InsP2) precede the onset of differentiation of these cells. These data therefore suggest that 1α,25-dihydroxyvitamin D3 functions in vitro to initiate the rapid generation of InsP3 from cellular polyPtdIns; this in turn may mobilize intracellular Ca2+, thus providing the signal which program the murine keratinocytes from a proliferating mode into a differentiating mode.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 131-136 |
| Number of pages | 6 |
| Journal | Journal of Cellular Physiology |
| Volume | 132 |
| Issue number | 1 |
| State | Published - 1987 |
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ASJC Scopus subject areas
- Cell Biology
- Clinical Biochemistry
- Physiology
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Novel regulatory actions of 1α,25-dihydroxyvitamin D3 on the metabolism of polyphosphoinositides in murine epidermal keratinocytes. / Tang, W.; Ziboh, V. A.; Isseroff, Roslyn Rivkah; Martinez, D.
In: Journal of Cellular Physiology, Vol. 132, No. 1, 1987, p. 131-136.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Novel regulatory actions of 1α,25-dihydroxyvitamin D3 on the metabolism of polyphosphoinositides in murine epidermal keratinocytes
AU - Tang, W.
AU - Ziboh, V. A.
AU - Isseroff, Roslyn Rivkah
AU - Martinez, D.
PY - 1987
Y1 - 1987
N2 - The in vitro incubation of murine keratinocytes in the presence of 1α,25-dihydroxyvitamin D3 enhanced the rapid hydrolysis of the prelabeled keratinocyte polyphosphoinositides (polyPtdIns) when compared to untreated cells. The rapid hydrolysis of the polyPtdIns and the release of the inositol phosphosphates (particularly InsP3 and InsP2) precede the onset of differentiation of these cells. These data therefore suggest that 1α,25-dihydroxyvitamin D3 functions in vitro to initiate the rapid generation of InsP3 from cellular polyPtdIns; this in turn may mobilize intracellular Ca2+, thus providing the signal which program the murine keratinocytes from a proliferating mode into a differentiating mode.
AB - The in vitro incubation of murine keratinocytes in the presence of 1α,25-dihydroxyvitamin D3 enhanced the rapid hydrolysis of the prelabeled keratinocyte polyphosphoinositides (polyPtdIns) when compared to untreated cells. The rapid hydrolysis of the polyPtdIns and the release of the inositol phosphosphates (particularly InsP3 and InsP2) precede the onset of differentiation of these cells. These data therefore suggest that 1α,25-dihydroxyvitamin D3 functions in vitro to initiate the rapid generation of InsP3 from cellular polyPtdIns; this in turn may mobilize intracellular Ca2+, thus providing the signal which program the murine keratinocytes from a proliferating mode into a differentiating mode.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023268810&partnerID=8YFLogxK
M3 - Article
C2 - 2439519
AN - SCOPUS:0023268810
VL - 132
SP - 131
EP - 136
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
SN - 0021-9541
IS - 1
ER -