Novel Redox-Responsive Polymeric Magnetosomes with Tunable Magnetic Resonance Property for In Vivo Drug Release Visualization and Dual-Modal Cancer Therapy

Zhongling Wang, Xiangdong Xue, Yixuan He, Ziwei Lu, Bei Jia, Hao Wu, Ye Yuan, Yee Huang, Han Wang, Hongwei Lu, Kit Lam, Tzu-Yin Lin, Yuanpei Li

Research output: Contribution to journalArticle

6 Scopus citations


Monitoring of in vivo drug release from nanotheranostics by noninvasive approaches remains very challenging. Herein, novel redox-responsive polymeric magnetosomes (PolyMags) with tunable magnetic resonance imaging (MRI) properties are reported for in vivo drug release monitoring and effective dual-modal cancer therapy. The encapsulation of doxorubicin (DOX) significantly decreases PolyMags' T2-contrast enhancement and transverse relaxation rate R2, depending on the drug loading level. The T2 enhancement and R2 can be recovered once the drug is released upon PolyMags' disassembly. T2- and T2*-MRI and diffusion-weighted imaging (DWI) are utilized to quantitatively study the correlation between MRI signal changes and drug release, and discover the MR tuning mechanisms. The in vivo drug release pattern is visualized based on such tunable MRI capability via monitoring the changes in T2-weighted images, T2 and T2* maps, and R2 and R2* values. Interestingly, the PolyMags possess excellent photothermal effect, which can be further enhanced upon DOX loading. The PolyMags are highly efficacious to treat breast tumors on xenograft model with tumor-targeted photothermal- and chemotherapy, achieving a complete cure rate of 66.7%. The concept reported here is generally applicable to other micellar and liposomal systems for image-guided drug delivery and release applications toward precision cancer therapy.

Original languageEnglish (US)
Article number1802159
JournalAdvanced Functional Materials
Issue number33
StatePublished - Aug 15 2018



  • cancer therapy
  • drug release
  • magnetic resonance imaging
  • nanoparticles

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Condensed Matter Physics
  • Electrochemistry

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