Novel polyomavirus associated with brain tumors in free-ranging raccoons, Western United States

Florante N. Dela Cruz, Federico Giannitti, Linlin Li, Leslie Woods, Luis Del Valle, Eric Delwart, Patricia Pesavento

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Tumors of any type are exceedingly rare in raccoons. High-grade brain tumors, consistently located in the frontal lobes and olfactory tracts, were detected in 10 raccoons during March 2010-May 2012 in California and Oregon, suggesting an emerging, infectious origin. We have identified a candidate etiologic agent, dubbed raccoon polyomavirus, that was present in the tumor tissue of all affected animals but not in tissues from 20 unaffected animals. Southern blot hybridization and rolling circle amplification showed the episomal viral genome in the tumors. The multifunctional nuclear protein large T-antigen was detectable by immunohistochemical analyses in a subset of neoplastic cells. Raccoon polyomavirus may contribute to the development of malignant brain tumors of raccoons.

Original languageEnglish (US)
Pages (from-to)77-84
Number of pages8
JournalEmerging Infectious Diseases
Volume19
Issue number1
DOIs
StatePublished - Jan 2013

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Raccoons
Polyomavirus
Brain Neoplasms
Neoplasms
Viral Genome
Olfactory Bulb
Viral Tumor Antigens
Frontal Lobe
Nuclear Proteins
Southern Blotting

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology

Cite this

Novel polyomavirus associated with brain tumors in free-ranging raccoons, Western United States. / Dela Cruz, Florante N.; Giannitti, Federico; Li, Linlin; Woods, Leslie; Del Valle, Luis; Delwart, Eric; Pesavento, Patricia.

In: Emerging Infectious Diseases, Vol. 19, No. 1, 01.2013, p. 77-84.

Research output: Contribution to journalArticle

Dela Cruz, Florante N. ; Giannitti, Federico ; Li, Linlin ; Woods, Leslie ; Del Valle, Luis ; Delwart, Eric ; Pesavento, Patricia. / Novel polyomavirus associated with brain tumors in free-ranging raccoons, Western United States. In: Emerging Infectious Diseases. 2013 ; Vol. 19, No. 1. pp. 77-84.
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