Novel optical oxy/deoxy hemoglobin monitoring as a modality for non-invasive real-time monitoring of cognitive activity and beyond

Dana Davies-Shaw, Thomas R Huser

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report on the successful development of a custom in vitro system that provides a physiologically relevant means of demonstrating optical methodologies for the calibration and validation of oxygen delivery and hemoglobin oxygen binding dynamics in the brain. While measured optical signals have generally been equated to heme absorbance values that are, in turn, presumed to correspond to oxygen delivery, there has been little specific study of the sigmoidal oxygen binding dynamics of hemoglobin, a tetrameric protein, within physiologically relevant parameters. Our development of this novel analytical device addresses this issue, and is a significant step towards the minimally invasive and real-time monitoring of spatially resolved cognitive processes. As such, it is of particular interest for the detection of autistic brain activity in infants and young children. Moreover, our device and approach bring with them the ability to quantify and spatially resolve oxygen delivery down to volumes relevant to individual cell oxygen uptake, without any oxygen consumption, and with a temporal resolution that is physically unachievable by any oxygen tracking modality such as fMRI etc. Such a capability opens up myriad possibilities for further investigation, such as real-time tumor biopsy and resection; the tracking and quantification of cellular proliferation, as well as metabolic measures of tissue viability, to name but a few. Our system has also been engineered to be synergistic with virtually all imaging techniques, optical and otherwise.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6863
DOIs
StatePublished - 2008
EventOptical Diagnostics and Sensing VIII - San Jose, CA, United States
Duration: Jan 21 2008Jan 23 2008

Other

OtherOptical Diagnostics and Sensing VIII
CountryUnited States
CitySan Jose, CA
Period1/21/081/23/08

Fingerprint

Hemoglobin
Oxygen
Monitoring
Brain
Biopsy
Tumors
Calibration
Tissue
Proteins
Imaging techniques

Keywords

  • Biomedical Imaging
  • Brain Function
  • Cognitive Activity
  • Hemoglobin Monitoring
  • Non-invasive Monitoring
  • Optical Imaging
  • Optical Sensing
  • Oxygen Sensing
  • Single Cell Oxygen Sensing

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Davies-Shaw, D., & Huser, T. R. (2008). Novel optical oxy/deoxy hemoglobin monitoring as a modality for non-invasive real-time monitoring of cognitive activity and beyond. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6863). [68630A] https://doi.org/10.1117/12.786491

Novel optical oxy/deoxy hemoglobin monitoring as a modality for non-invasive real-time monitoring of cognitive activity and beyond. / Davies-Shaw, Dana; Huser, Thomas R.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6863 2008. 68630A.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Davies-Shaw, D & Huser, TR 2008, Novel optical oxy/deoxy hemoglobin monitoring as a modality for non-invasive real-time monitoring of cognitive activity and beyond. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 6863, 68630A, Optical Diagnostics and Sensing VIII, San Jose, CA, United States, 1/21/08. https://doi.org/10.1117/12.786491
Davies-Shaw D, Huser TR. Novel optical oxy/deoxy hemoglobin monitoring as a modality for non-invasive real-time monitoring of cognitive activity and beyond. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6863. 2008. 68630A https://doi.org/10.1117/12.786491
Davies-Shaw, Dana ; Huser, Thomas R. / Novel optical oxy/deoxy hemoglobin monitoring as a modality for non-invasive real-time monitoring of cognitive activity and beyond. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6863 2008.
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