Novel optical oxy/deoxy hemoglobin monitoring as a modality for non-invasive real-time monitoring of cognitive activity and beyond

Dana Davies-Shaw, Thomas R Huser

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We report on the successful development of a custom in vitro system that provides a physiologically relevant means of demonstrating optical methodologies for the calibration and validation of oxygen delivery and hemoglobin oxygen binding dynamics in the brain. While measured optical signals have generally been equated to heme absorbance values that are, in turn, presumed to correspond to oxygen delivery, there has been little specific study of the sigmoidal oxygen binding dynamics of hemoglobin, a tetrameric protein, within physiologically relevant parameters. Our development of this novel analytical device addresses this issue, and is a significant step towards the minimally invasive and real-time monitoring of spatially resolved cognitive processes. As such, it is of particular interest for the detection of autistic brain activity in infants and young children. Moreover, our device and approach bring with them the ability to quantify and spatially resolve oxygen delivery down to volumes relevant to individual cell oxygen uptake, without any oxygen consumption, and with a temporal resolution that is physically unachievable by any oxygen tracking modality such as fMRI etc. Such a capability opens up myriad possibilities for further investigation, such as real-time tumor biopsy and resection; the tracking and quantification of cellular proliferation, as well as metabolic measures of tissue viability, to name but a few. Our system has also been engineered to be synergistic with virtually all imaging techniques, optical and otherwise.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
StatePublished - 2008
EventOptical Diagnostics and Sensing VIII - San Jose, CA, United States
Duration: Jan 21 2008Jan 23 2008


OtherOptical Diagnostics and Sensing VIII
Country/TerritoryUnited States
CitySan Jose, CA


  • Biomedical Imaging
  • Brain Function
  • Cognitive Activity
  • Hemoglobin Monitoring
  • Non-invasive Monitoring
  • Optical Imaging
  • Optical Sensing
  • Oxygen Sensing
  • Single Cell Oxygen Sensing

ASJC Scopus subject areas

  • Engineering(all)


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