Novel MLL-CBP fusion transcript in therapy-related chronic myelomonocytic leukemia with a t(11;16) (q23;p13) chromosome translocation

Noriko Satake, Yasushi Ishida, Yoshiko Otoh, Shin Ichi Hinohara, Hirofumi Kobayashi, Akiko Sakashita, Nobuo Maseki, Yasuhiko Kaneko

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

CBP, which is located on 16p13 and encodes a transcriptional adaptor/coactivator protein, has been shown to fuse by the t(8;16)(p11;p13) translocation to MOZ on 8p11 in acute myeloid leukemia. We found a t(11;16)(q23;p13) in a child with therapy-related chronic myelomonocytic leukemia. Subsequent reverse transcriptase-polymerase chain reaction and direct sequencing analyses revealed the MLL-CBP fusion transcript in CMML cells. Because 11q23 translocations involving MLL and t(8;16) involving MOZ and CBP have been reported in therapy-related leukemias, both the MLL and CBP genes may be targets for topoisomerase II inhibitors. Accordingly, we believe that most t(11;16)-associated leukemias may develop in patients who have been treated with cytotoxic chemotherapy for primary malignant diseases.

Original languageEnglish (US)
Pages (from-to)60-63
Number of pages4
JournalGenes Chromosomes and Cancer
Volume20
Issue number1
DOIs
StatePublished - Sep 1997
Externally publishedYes

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Leukemia, Myelomonocytic, Chronic
Leukemia
Chromosomes
Topoisomerase II Inhibitors
Reverse Transcriptase Polymerase Chain Reaction
Acute Myeloid Leukemia
Drug Therapy
Therapeutics
Genes
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

Novel MLL-CBP fusion transcript in therapy-related chronic myelomonocytic leukemia with a t(11;16) (q23;p13) chromosome translocation. / Satake, Noriko; Ishida, Yasushi; Otoh, Yoshiko; Hinohara, Shin Ichi; Kobayashi, Hirofumi; Sakashita, Akiko; Maseki, Nobuo; Kaneko, Yasuhiko.

In: Genes Chromosomes and Cancer, Vol. 20, No. 1, 09.1997, p. 60-63.

Research output: Contribution to journalArticle

Satake, Noriko ; Ishida, Yasushi ; Otoh, Yoshiko ; Hinohara, Shin Ichi ; Kobayashi, Hirofumi ; Sakashita, Akiko ; Maseki, Nobuo ; Kaneko, Yasuhiko. / Novel MLL-CBP fusion transcript in therapy-related chronic myelomonocytic leukemia with a t(11;16) (q23;p13) chromosome translocation. In: Genes Chromosomes and Cancer. 1997 ; Vol. 20, No. 1. pp. 60-63.
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AU - Satake, Noriko

AU - Ishida, Yasushi

AU - Otoh, Yoshiko

AU - Hinohara, Shin Ichi

AU - Kobayashi, Hirofumi

AU - Sakashita, Akiko

AU - Maseki, Nobuo

AU - Kaneko, Yasuhiko

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