Novel insights into human lactation as a driver of infant formula development

Bo Lönnerdal

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Progress in research on human lactation and breast milk has advanced our knowledge about the significance of breast milk for the recipient infant and the effects of various components on long-term outcomes. Recent findings have expanded our knowledge in this area. Several growth factors and cytokines are present in breast milk and their capacity to persist in the infant gut and exert their activities is likely to affect maturation of immune function, possibly affecting the development of oral tolerance. A proper balance of polyunsaturated fatty acids (n-3/n-6 ratio) may also be of significance for allergy prevention in children, emphasizing the need for the mother to achieve a balance of these fatty acids in her diet. The recent findings that specific strains of bacteria are present in breast milk and act as probiotics in the early colonization of the infant gut and that human milk oligosaccharides are specific substrates for these probiotic strains may not only affect the defense against pathogens, but also affect energy utilization and development of obesity. Previously neglected milk fat globule membranes contain several components involved in protection against infection and may be an additional arm in the multifaceted shield that breastfed infants have developed against bacterial and viral antagonists. All these findings have implications for development of improved infant formulae.

Original languageEnglish (US)
Title of host publicationNestle Nutrition Workshop Series: Pediatric Program
Pages19-29
Number of pages11
Volume66
DOIs
StatePublished - Jul 2010

Publication series

NameNestle Nutrition Workshop Series: Pediatric Program
Volume66
ISSN (Print)16616677
ISSN (Electronic)16623878

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Food Science
  • Nutrition and Dietetics

Cite this

Lönnerdal, B. (2010). Novel insights into human lactation as a driver of infant formula development. In Nestle Nutrition Workshop Series: Pediatric Program (Vol. 66, pp. 19-29). (Nestle Nutrition Workshop Series: Pediatric Program; Vol. 66). https://doi.org/10.1159/000318945