Novel homologs of replication protein A in Archaea: Implications for the evolution of ssDNA-binding proteins

Frederic Chedin, Erica M. Seitz, Stephen C. Kowalczykowski

Research output: Contribution to journalArticle

56 Scopus citations


In Bacteria and Eukarya, ssDNA-binding proteins are central to most aspects of DNA metabolism. Until recently, however, no counterpart of an ssDNA-binding protein had been identified in the third domain of life, Archaea. Here, we report the discovery of a novel type of ssDNA-binding protein in the genomes of several archaeons. These proteins, in contrast to all known members of this protein family, possess four conserved DNA-binding sites within a single polypeptide or, in one case, two polypeptides. This peculiar structural organization allows us to propose a model for the evolution of this class of proteins. Copyright (C) 1998 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)273-277
Number of pages5
JournalTrends in Biochemical Sciences
Issue number8
StatePublished - Aug 1 1998


ASJC Scopus subject areas

  • Biochemistry

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