Novel gastric helicobacters and oral campylobacters are present in captive and wild cetaceans

Cinthia G. Goldman, Mario J. Matteo, Julio D. Loureiro, Marisa Almuzara, Claudia Barberis, Carlos Vay, Mariana Catalano, Sergio Rodríguez Heredia, Paula Mantero, Jose R. Boccio, Marcela B. Zubillaga, Graciela A. Cremaschi, Jay V Solnick, Guillermo I. Perez-Perez, Martin J. Blaser

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The mammalian gastric and oral mucosa may be colonized by mixed Helicobacter and Campylobacter species, respectively, in individual animals. To better characterize the presence and distribution of Helicobacter and Campylobacter among marine mammals, we used PCR and 16S rDNA sequence analysis to examine gastric and oral samples from ten dolphins (Tursiops gephyreus), one killer whale (Orcinus orca), one false killer whale (Pseudorca crassidens), and three wild La Plata river dolphins (Pontoporia blainvillei). Helicobacter spp. DNA was widely distributed in gastric and oral samples from both captive and wild cetaceans. Phylogenetic analysis demonstrated two Helicobacter sequence clusters, one closely related to H. cetorum, a species isolated from dolphins and whales in North America. The second related cluster was to sequences obtained from dolphins in Australia and to gastric non-H. pylori helicobacters, and may represent a novel taxonomic group. Dental plaque sequences from four dolphins formed a third cluster within the Campylobacter genus that likely represents a novel species isolated from marine mammals. Identification of identical Helicobacter spp. DNA sequences from dental plaque, saliva and gastric fluids from the same hosts, suggests that the oral cavity may be involved in transmission. These results demonstrate that Helicobacter and Campylobacter species are commonly distributed in marine mammals, and identify taxonomic clusters that may represent novel species.

Original languageEnglish (US)
Pages (from-to)138-145
Number of pages8
JournalVeterinary Microbiology
Volume152
Issue number1-2
DOIs
StatePublished - Aug 26 2011

Keywords

  • Campylobacter
  • Cetaceans
  • Gastritis
  • Helicobacter
  • Marine mammals

ASJC Scopus subject areas

  • Microbiology
  • veterinary(all)

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    Goldman, C. G., Matteo, M. J., Loureiro, J. D., Almuzara, M., Barberis, C., Vay, C., Catalano, M., Heredia, S. R., Mantero, P., Boccio, J. R., Zubillaga, M. B., Cremaschi, G. A., Solnick, J. V., Perez-Perez, G. I., & Blaser, M. J. (2011). Novel gastric helicobacters and oral campylobacters are present in captive and wild cetaceans. Veterinary Microbiology, 152(1-2), 138-145. https://doi.org/10.1016/j.vetmic.2011.04.023