Novel fret-based radiosensitization using quantum dot-photosensitizer conjugates

Wensha Yang, Paul W. Read, Jun Mi, James M. Larner, Stanley H Benedict, Ke Sheng, Brian P. Helmke

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

A novel radiosensitizer was synthesized by covalently conjugating quantum dots (QDs) to a photosensitizer. We hypothesized that QDs excited by 6-MV X-rays would serve as an energy donor to activate the photosensitizer. Photon emission from QDs was linearly proportional to radiation dose rate. Donor quenching in conjugates indicated that activation of photosensitizer occurred by Förster resonance energy transfer. Radiation treatment of lung carcinoma cells with conjugate increased cell killing by 34% compared to radiation alone. Cell toxicity in non-irradiated controls was negligible. Thus, this conjugate acts via a novel mechanism of radiosensitization that will improve treatment of deeply seated tumors.

Original languageEnglish (US)
Title of host publicationConference Record - Asilomar Conference on Signals, Systems and Computers
Pages1861-1865
Number of pages5
DOIs
StatePublished - 2007
Externally publishedYes
Event41st Asilomar Conference on Signals, Systems and Computers, ACSSC - Pacific Grove, CA, United States
Duration: Nov 4 2007Nov 7 2007

Other

Other41st Asilomar Conference on Signals, Systems and Computers, ACSSC
CountryUnited States
CityPacific Grove, CA
Period11/4/0711/7/07

Fingerprint

Photosensitizers
Semiconductor quantum dots
Cells
Radiation
Energy transfer
Dosimetry
Toxicity
Tumors
Quenching
Photons
Chemical activation
X rays

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Yang, W., Read, P. W., Mi, J., Larner, J. M., Benedict, S. H., Sheng, K., & Helmke, B. P. (2007). Novel fret-based radiosensitization using quantum dot-photosensitizer conjugates. In Conference Record - Asilomar Conference on Signals, Systems and Computers (pp. 1861-1865). [4487558] https://doi.org/10.1109/ACSSC.2007.4487558

Novel fret-based radiosensitization using quantum dot-photosensitizer conjugates. / Yang, Wensha; Read, Paul W.; Mi, Jun; Larner, James M.; Benedict, Stanley H; Sheng, Ke; Helmke, Brian P.

Conference Record - Asilomar Conference on Signals, Systems and Computers. 2007. p. 1861-1865 4487558.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yang, W, Read, PW, Mi, J, Larner, JM, Benedict, SH, Sheng, K & Helmke, BP 2007, Novel fret-based radiosensitization using quantum dot-photosensitizer conjugates. in Conference Record - Asilomar Conference on Signals, Systems and Computers., 4487558, pp. 1861-1865, 41st Asilomar Conference on Signals, Systems and Computers, ACSSC, Pacific Grove, CA, United States, 11/4/07. https://doi.org/10.1109/ACSSC.2007.4487558
Yang W, Read PW, Mi J, Larner JM, Benedict SH, Sheng K et al. Novel fret-based radiosensitization using quantum dot-photosensitizer conjugates. In Conference Record - Asilomar Conference on Signals, Systems and Computers. 2007. p. 1861-1865. 4487558 https://doi.org/10.1109/ACSSC.2007.4487558
Yang, Wensha ; Read, Paul W. ; Mi, Jun ; Larner, James M. ; Benedict, Stanley H ; Sheng, Ke ; Helmke, Brian P. / Novel fret-based radiosensitization using quantum dot-photosensitizer conjugates. Conference Record - Asilomar Conference on Signals, Systems and Computers. 2007. pp. 1861-1865
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