Novel features of the respiratory tract T-cell response to influenza virus infection: Lung T cells increase expression of gamma interferon mRNA in vivo and maintain high levels of mRNA expression for interleukin-5 (IL-5) and IL-10

Nicole Baumgarth, Lorena Brown, David Jackson, Anne Kelso

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

Analysis of the respiratory tract before and after primary influenza virus infection revealed a virus-induced preferential accumulation of a CD8+ T-cell population that coexpresses mRNA for interleukin-5 (IL-5) and IL-10 with virus dose-dependent high levels of gamma interferon. However, cytokine production in lung tissues was not restricted to the T-cell population, since CD3- cells were found to express mRNA for various cytokines, including IL-4 and particularly IL-6 and granulocyte-macrophage colony-stimulating factor. These data provide in vivo evidence for a local respiratory tract immune response to influenza virus infection dominated by cytokine-producing CD8+ T cells.

Original languageEnglish (US)
Pages (from-to)7575-7581
Number of pages7
JournalJournal of Virology
Volume68
Issue number11
StatePublished - Nov 1994
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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