Novel biodegradable films and scaffolds of chitosan blended with poly(3-hydroxybutyrate)

Wenling Cao, Aijun Wang, Duohui Jing, Yandao Gong, Nanming Zhao, Xiufang Zhang

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

In order to develop a novel biomaterial, films of chitosan blended with poly(3-hydroxybutyrate) (PHB) were prepared by an emulsion blending technique and their properties were characterized. Scanning electron microscopy (SEM) showed that PHB microspheres were formed and were entrapped in chitosan matrices, which made the film surface rough. With increasing PHB content, the roughness of the film surface increased, while the swelling capability of the films decreased. In a wet state, the blended films exhibited a lower elastic modulus, a higher elongation-at-break and a higher tensile strength compared with chitosan films. Cell-culture experiments revealed that the blended films had better cytocompatibility than chitosan films. To explore the potential application of the blended material in tissue engineering, the porous blended scaffolds were fabricated and their pore morphology was observed by SEM. The results revealed that not only pore structure but also pore wall morphology of the blended scaffolds could be controlled by selecting the parameters of the fabrication process. These advantageous properties indicate that the blended chitosan/PHB material is promising for tissue engineering applications.

Original languageEnglish (US)
Pages (from-to)1379-1394
Number of pages16
JournalJournal of Biomaterials Science, Polymer Edition
Volume16
Issue number11
DOIs
StatePublished - Nov 2005
Externally publishedYes

Keywords

  • Chitosan
  • Emulsion blending
  • Mechanical properties
  • Poly(3-hydroxybutyrate)
  • Porous blended scaffold

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials

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