Novel analogues of enkephalin: Identification of functional groups required for biological activity

Fredric A Gorin, T. M. Balasubramanian, Theodore J. Cicero, John Schwietzer, Garland R. Marshall

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Novel tri- and tetrapeptide analogues of enkephalin, in conjunction with earlier structure-activity data, confirm that chemical substituents present in the first and fourth residues of enkephalin are required for in vitro biological activity. A class of arylamino and alkylamino derivatized tripeptides also were found to have signficiant in vitro opioid-like activity indistinguishable from [D-Ala2,D-Leu5]enkephalin and morphine.

Original languageEnglish (US)
Pages (from-to)1113-1122
Number of pages10
JournalJournal of Medicinal Chemistry
Volume23
Issue number10
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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    Gorin, F. A., Balasubramanian, T. M., Cicero, T. J., Schwietzer, J., & Marshall, G. R. (1980). Novel analogues of enkephalin: Identification of functional groups required for biological activity. Journal of Medicinal Chemistry, 23(10), 1113-1122.