Novel tri- and tetrapeptide analogues of enkephalin, in conjunction with earlier structure-activity data, confirm that chemical substituents present in the first and fourth residues of enkephalin are required for in vitro biological activity. A class of arylamino and alkylamino derivatized tripeptides also were found to have signficiant in vitro opioid-like activity indistinguishable from [D-Ala2,D-Leu5]enkephalin and morphine.
|Original language||English (US)|
|Number of pages||10|
|Journal||Journal of Medicinal Chemistry|
|State||Published - 1980|
ASJC Scopus subject areas
- Organic Chemistry