Novel analogues of enkephalin

Identification of functional groups required for biological activity

Fredric A Gorin, T. M. Balasubramanian, Theodore J. Cicero, John Schwietzer, Garland R. Marshall

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Novel tri- and tetrapeptide analogues of enkephalin, in conjunction with earlier structure-activity data, confirm that chemical substituents present in the first and fourth residues of enkephalin are required for in vitro biological activity. A class of arylamino and alkylamino derivatized tripeptides also were found to have signficiant in vitro opioid-like activity indistinguishable from [D-Ala2,D-Leu5]enkephalin and morphine.

Original languageEnglish (US)
Pages (from-to)1113-1122
Number of pages10
JournalJournal of Medicinal Chemistry
Volume23
Issue number10
StatePublished - 1980
Externally publishedYes

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Social Identification
Enkephalins
Bioactivity
Functional groups
Morphine
Opioid Analgesics
In Vitro Techniques
Ala(2)-enkephalinamide-met

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Gorin, F. A., Balasubramanian, T. M., Cicero, T. J., Schwietzer, J., & Marshall, G. R. (1980). Novel analogues of enkephalin: Identification of functional groups required for biological activity. Journal of Medicinal Chemistry, 23(10), 1113-1122.

Novel analogues of enkephalin : Identification of functional groups required for biological activity. / Gorin, Fredric A; Balasubramanian, T. M.; Cicero, Theodore J.; Schwietzer, John; Marshall, Garland R.

In: Journal of Medicinal Chemistry, Vol. 23, No. 10, 1980, p. 1113-1122.

Research output: Contribution to journalArticle

Gorin, FA, Balasubramanian, TM, Cicero, TJ, Schwietzer, J & Marshall, GR 1980, 'Novel analogues of enkephalin: Identification of functional groups required for biological activity', Journal of Medicinal Chemistry, vol. 23, no. 10, pp. 1113-1122.
Gorin, Fredric A ; Balasubramanian, T. M. ; Cicero, Theodore J. ; Schwietzer, John ; Marshall, Garland R. / Novel analogues of enkephalin : Identification of functional groups required for biological activity. In: Journal of Medicinal Chemistry. 1980 ; Vol. 23, No. 10. pp. 1113-1122.
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