Abstract
Vitamin B12 turnover studies were carried out in 2 patients with pernicious anemia and subacute combined degeneration of the spinal cord. The retention of a tracer dose (0.5 μg) of intravenously administered 58Co-labeled vitamin B12 in these 2 patients was measured by whole-body monitoring over periods of 94 and 134 days. Vitamin B12 turnover (per cent per day) was calculated and the results compared with normal subjects and with pernicious anemia patients having no neurologic dysfunction. The loss of radioactive-B12 from the body was described by a single exponential model, confirming that the loss of vitamin B12 takes place as though from a single pool. There was no difference in vitamin B12 turnover between the patients with subacute combined degeneration of the spinal cord and normal subjects or other pernicious anemia patients without neurologic involvement. These findings contradict the suggestion that the development of neuropathy in vitamin B12 deficiency might be related to an increased requirement for vitamin B12.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 667-671 |
| Number of pages | 5 |
| Journal | The Journal of Laboratory and Clinical Medicine |
| Volume | 86 |
| Issue number | 4 |
| State | Published - 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
- Pathology and Forensic Medicine
Cite this
Normal vitamin B12 turnover in subacute combined degeneration of the spinal cord. / Mendelsohn, Geoffrey; Metz, Jack; Green, Ralph.
In: The Journal of Laboratory and Clinical Medicine, Vol. 86, No. 4, 1975, p. 667-671.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Normal vitamin B12 turnover in subacute combined degeneration of the spinal cord
AU - Mendelsohn, Geoffrey
AU - Metz, Jack
AU - Green, Ralph
PY - 1975
Y1 - 1975
N2 - Vitamin B12 turnover studies were carried out in 2 patients with pernicious anemia and subacute combined degeneration of the spinal cord. The retention of a tracer dose (0.5 μg) of intravenously administered 58Co-labeled vitamin B12 in these 2 patients was measured by whole-body monitoring over periods of 94 and 134 days. Vitamin B12 turnover (per cent per day) was calculated and the results compared with normal subjects and with pernicious anemia patients having no neurologic dysfunction. The loss of radioactive-B12 from the body was described by a single exponential model, confirming that the loss of vitamin B12 takes place as though from a single pool. There was no difference in vitamin B12 turnover between the patients with subacute combined degeneration of the spinal cord and normal subjects or other pernicious anemia patients without neurologic involvement. These findings contradict the suggestion that the development of neuropathy in vitamin B12 deficiency might be related to an increased requirement for vitamin B12.
AB - Vitamin B12 turnover studies were carried out in 2 patients with pernicious anemia and subacute combined degeneration of the spinal cord. The retention of a tracer dose (0.5 μg) of intravenously administered 58Co-labeled vitamin B12 in these 2 patients was measured by whole-body monitoring over periods of 94 and 134 days. Vitamin B12 turnover (per cent per day) was calculated and the results compared with normal subjects and with pernicious anemia patients having no neurologic dysfunction. The loss of radioactive-B12 from the body was described by a single exponential model, confirming that the loss of vitamin B12 takes place as though from a single pool. There was no difference in vitamin B12 turnover between the patients with subacute combined degeneration of the spinal cord and normal subjects or other pernicious anemia patients without neurologic involvement. These findings contradict the suggestion that the development of neuropathy in vitamin B12 deficiency might be related to an increased requirement for vitamin B12.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016594106&partnerID=8YFLogxK
M3 - Article
VL - 86
SP - 667
EP - 671
JO - Translational Research
JF - Translational Research
SN - 1931-5244
IS - 4
ER -