Abstract
The normal range of human erythrocyte acetylcholinesterase (RBC-AChE) activity is important when monitoring exposure to pesticides and chemical warfare agents. A modification of Michel's method measured RBC-AChE activities from 991 individuals (818 males and 173 females) presumably unexposed to nerve agents. Median age was 42 (range, 18-76) years. RBC-AChE (mean ± SD) was 0.74±0.06 delta pH units/hour. Multivariate linear regression showed an association with age (slope 0.0008 delta pH units/hour for each year; P<0.001) unlikely to be clinically significant. The findings represent the largest study of human RBC-AChE to date providing measures of central tendency and variation.
Original language | English (US) |
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Pages (from-to) | 182-185 |
Number of pages | 4 |
Journal | Drug and Chemical Toxicology |
Volume | 32 |
Issue number | 3 |
DOIs | |
State | Published - Jul 2009 |
Keywords
- Acetylcholinesterase
- Human
- Red blood cell
ASJC Scopus subject areas
- Toxicology
- Pharmacology
- Health, Toxicology and Mutagenesis
- Public Health, Environmental and Occupational Health
- Chemical Health and Safety