Normal range of human red blood cell acetylcholinesterase activity

Daniel E. Arrieta; Stephen A Mccurdy; John D. Henderson; Lee J. Lefkowitz; Raven Reitstetter; Barry W. Wilson

doi:10.1080/01480540902863440

Normal range of human red blood cell acetylcholinesterase activity

Daniel E. Arrieta, Stephen A Mccurdy, John D. Henderson, Lee J. Lefkowitz, Raven Reitstetter, Barry W. Wilson

Public Health Sciences

Research output: Contribution to journal › Article

15 Scopus citations

Abstract

The normal range of human erythrocyte acetylcholinesterase (RBC-AChE) activity is important when monitoring exposure to pesticides and chemical warfare agents. A modification of Michel's method measured RBC-AChE activities from 991 individuals (818 males and 173 females) presumably unexposed to nerve agents. Median age was 42 (range, 18-76) years. RBC-AChE (mean ± SD) was 0.74±0.06 delta pH units/hour. Multivariate linear regression showed an association with age (slope 0.0008 delta pH units/hour for each year; P<0.001) unlikely to be clinically significant. The findings represent the largest study of human RBC-AChE to date providing measures of central tendency and variation.

Original language	English (US)
Pages (from-to)	182-185
Number of pages	4
Journal	Drug and Chemical Toxicology
Volume	32
Issue number	3
DOIs	https://doi.org/10.1080/01480540902863440
State	Published - Jul 2009

Keywords

Acetylcholinesterase
Human
Red blood cell

ASJC Scopus subject areas

Toxicology
Pharmacology
Health, Toxicology and Mutagenesis
Public Health, Environmental and Occupational Health
Chemical Health and Safety

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Arrieta, D. E., Mccurdy, S. A., Henderson, J. D., Lefkowitz, L. J., Reitstetter, R., & Wilson, B. W. (2009). Normal range of human red blood cell acetylcholinesterase activity. Drug and Chemical Toxicology, 32(3), 182-185. https://doi.org/10.1080/01480540902863440

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