Normal range of human red blood cell acetylcholinesterase activity

Daniel E. Arrieta, Stephen A Mccurdy, John D. Henderson, Lee J. Lefkowitz, Raven Reitstetter, Barry W. Wilson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The normal range of human erythrocyte acetylcholinesterase (RBC-AChE) activity is important when monitoring exposure to pesticides and chemical warfare agents. A modification of Michel's method measured RBC-AChE activities from 991 individuals (818 males and 173 females) presumably unexposed to nerve agents. Median age was 42 (range, 18-76) years. RBC-AChE (mean ± SD) was 0.74±0.06 delta pH units/hour. Multivariate linear regression showed an association with age (slope 0.0008 delta pH units/hour for each year; P<0.001) unlikely to be clinically significant. The findings represent the largest study of human RBC-AChE to date providing measures of central tendency and variation.

Original languageEnglish (US)
Pages (from-to)182-185
Number of pages4
JournalDrug and Chemical Toxicology
Issue number3
StatePublished - Jul 2009


  • Acetylcholinesterase
  • Human
  • Red blood cell

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Chemical Health and Safety


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