Normal range of human red blood cell acetylcholinesterase activity

Daniel E. Arrieta, Stephen A Mccurdy, John D. Henderson, Lee J. Lefkowitz, Raven Reitstetter, Barry W. Wilson

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The normal range of human erythrocyte acetylcholinesterase (RBC-AChE) activity is important when monitoring exposure to pesticides and chemical warfare agents. A modification of Michel's method measured RBC-AChE activities from 991 individuals (818 males and 173 females) presumably unexposed to nerve agents. Median age was 42 (range, 18-76) years. RBC-AChE (mean ± SD) was 0.74±0.06 delta pH units/hour. Multivariate linear regression showed an association with age (slope 0.0008 delta pH units/hour for each year; P<0.001) unlikely to be clinically significant. The findings represent the largest study of human RBC-AChE to date providing measures of central tendency and variation.

Original languageEnglish (US)
Pages (from-to)182-185
Number of pages4
JournalDrug and Chemical Toxicology
Volume32
Issue number3
DOIs
StatePublished - Jul 2009

    Fingerprint

Keywords

  • Acetylcholinesterase
  • Human
  • Red blood cell

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Chemical Health and Safety

Cite this

Arrieta, D. E., Mccurdy, S. A., Henderson, J. D., Lefkowitz, L. J., Reitstetter, R., & Wilson, B. W. (2009). Normal range of human red blood cell acetylcholinesterase activity. Drug and Chemical Toxicology, 32(3), 182-185. https://doi.org/10.1080/01480540902863440