Normal range of human red blood cell acetylcholinesterase activity

Daniel E. Arrieta, Stephen A Mccurdy, John D. Henderson, Lee J. Lefkowitz, Raven Reitstetter, Barry W. Wilson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The normal range of human erythrocyte acetylcholinesterase (RBC-AChE) activity is important when monitoring exposure to pesticides and chemical warfare agents. A modification of Michel's method measured RBC-AChE activities from 991 individuals (818 males and 173 females) presumably unexposed to nerve agents. Median age was 42 (range, 18-76) years. RBC-AChE (mean ± SD) was 0.74±0.06 delta pH units/hour. Multivariate linear regression showed an association with age (slope 0.0008 delta pH units/hour for each year; P<0.001) unlikely to be clinically significant. The findings represent the largest study of human RBC-AChE to date providing measures of central tendency and variation.

Original languageEnglish (US)
Pages (from-to)182-185
Number of pages4
JournalDrug and Chemical Toxicology
Volume32
Issue number3
DOIs
StatePublished - Jul 2009

Fingerprint

Chemical Warfare Agents
Proton-Motive Force
Acetylcholinesterase
Pesticides
Linear regression
Reference Values
Blood
Erythrocytes
Cells
Chemical warfare
Monitoring
Linear Models
Nerve Agents

Keywords

  • Acetylcholinesterase
  • Human
  • Red blood cell

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Chemical Health and Safety

Cite this

Arrieta, D. E., Mccurdy, S. A., Henderson, J. D., Lefkowitz, L. J., Reitstetter, R., & Wilson, B. W. (2009). Normal range of human red blood cell acetylcholinesterase activity. Drug and Chemical Toxicology, 32(3), 182-185. https://doi.org/10.1080/01480540902863440

Normal range of human red blood cell acetylcholinesterase activity. / Arrieta, Daniel E.; Mccurdy, Stephen A; Henderson, John D.; Lefkowitz, Lee J.; Reitstetter, Raven; Wilson, Barry W.

In: Drug and Chemical Toxicology, Vol. 32, No. 3, 07.2009, p. 182-185.

Research output: Contribution to journalArticle

Arrieta, DE, Mccurdy, SA, Henderson, JD, Lefkowitz, LJ, Reitstetter, R & Wilson, BW 2009, 'Normal range of human red blood cell acetylcholinesterase activity', Drug and Chemical Toxicology, vol. 32, no. 3, pp. 182-185. https://doi.org/10.1080/01480540902863440
Arrieta, Daniel E. ; Mccurdy, Stephen A ; Henderson, John D. ; Lefkowitz, Lee J. ; Reitstetter, Raven ; Wilson, Barry W. / Normal range of human red blood cell acetylcholinesterase activity. In: Drug and Chemical Toxicology. 2009 ; Vol. 32, No. 3. pp. 182-185.
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