Normal range of human red blood cell acetylcholinesterase activity

Daniel E. Arrieta; Stephen A Mccurdy; John D. Henderson; Lee J. Lefkowitz; Raven Reitstetter; Barry W. Wilson

doi:10.1080/01480540902863440

Normal range of human red blood cell acetylcholinesterase activity

Daniel E. Arrieta, Stephen A Mccurdy, John D. Henderson, Lee J. Lefkowitz, Raven Reitstetter, Barry W. Wilson

Public Health Sciences

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The normal range of human erythrocyte acetylcholinesterase (RBC-AChE) activity is important when monitoring exposure to pesticides and chemical warfare agents. A modification of Michel's method measured RBC-AChE activities from 991 individuals (818 males and 173 females) presumably unexposed to nerve agents. Median age was 42 (range, 18-76) years. RBC-AChE (mean ± SD) was 0.74±0.06 delta pH units/hour. Multivariate linear regression showed an association with age (slope 0.0008 delta pH units/hour for each year; P<0.001) unlikely to be clinically significant. The findings represent the largest study of human RBC-AChE to date providing measures of central tendency and variation.

Original language	English (US)
Pages (from-to)	182-185
Number of pages	4
Journal	Drug and Chemical Toxicology
Volume	32
Issue number	3
DOIs	https://doi.org/10.1080/01480540902863440
State	Published - Jul 2009

Keywords

Acetylcholinesterase
Human
Red blood cell

ASJC Scopus subject areas

Toxicology
Pharmacology
Health, Toxicology and Mutagenesis
Public Health, Environmental and Occupational Health
Chemical Health and Safety

Access to Document

10.1080/01480540902863440

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abstract = "The normal range of human erythrocyte acetylcholinesterase (RBC-AChE) activity is important when monitoring exposure to pesticides and chemical warfare agents. A modification of Michel's method measured RBC-AChE activities from 991 individuals (818 males and 173 females) presumably unexposed to nerve agents. Median age was 42 (range, 18-76) years. RBC-AChE (mean ± SD) was 0.74±0.06 delta pH units/hour. Multivariate linear regression showed an association with age (slope 0.0008 delta pH units/hour for each year; P<0.001) unlikely to be clinically significant. The findings represent the largest study of human RBC-AChE to date providing measures of central tendency and variation.",

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AU - Mccurdy, Stephen A

AU - Henderson, John D.

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AU - Reitstetter, Raven

AU - Wilson, Barry W.

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