Abstract
The normal range of human erythrocyte acetylcholinesterase (RBC-AChE) activity is important when monitoring exposure to pesticides and chemical warfare agents. A modification of Michel's method measured RBC-AChE activities from 991 individuals (818 males and 173 females) presumably unexposed to nerve agents. Median age was 42 (range, 18-76) years. RBC-AChE (mean ± SD) was 0.74±0.06 delta pH units/hour. Multivariate linear regression showed an association with age (slope 0.0008 delta pH units/hour for each year; P<0.001) unlikely to be clinically significant. The findings represent the largest study of human RBC-AChE to date providing measures of central tendency and variation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 182-185 |
| Number of pages | 4 |
| Journal | Drug and Chemical Toxicology |
| Volume | 32 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 2009 |
Fingerprint
Keywords
- Acetylcholinesterase
- Human
- Red blood cell
ASJC Scopus subject areas
- Toxicology
- Pharmacology
- Health, Toxicology and Mutagenesis
- Public Health, Environmental and Occupational Health
- Chemical Health and Safety
Cite this
Normal range of human red blood cell acetylcholinesterase activity. / Arrieta, Daniel E.; Mccurdy, Stephen A; Henderson, John D.; Lefkowitz, Lee J.; Reitstetter, Raven; Wilson, Barry W.
In: Drug and Chemical Toxicology, Vol. 32, No. 3, 07.2009, p. 182-185.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Normal range of human red blood cell acetylcholinesterase activity
AU - Arrieta, Daniel E.
AU - Mccurdy, Stephen A
AU - Henderson, John D.
AU - Lefkowitz, Lee J.
AU - Reitstetter, Raven
AU - Wilson, Barry W.
PY - 2009/7
Y1 - 2009/7
N2 - The normal range of human erythrocyte acetylcholinesterase (RBC-AChE) activity is important when monitoring exposure to pesticides and chemical warfare agents. A modification of Michel's method measured RBC-AChE activities from 991 individuals (818 males and 173 females) presumably unexposed to nerve agents. Median age was 42 (range, 18-76) years. RBC-AChE (mean ± SD) was 0.74±0.06 delta pH units/hour. Multivariate linear regression showed an association with age (slope 0.0008 delta pH units/hour for each year; P<0.001) unlikely to be clinically significant. The findings represent the largest study of human RBC-AChE to date providing measures of central tendency and variation.
AB - The normal range of human erythrocyte acetylcholinesterase (RBC-AChE) activity is important when monitoring exposure to pesticides and chemical warfare agents. A modification of Michel's method measured RBC-AChE activities from 991 individuals (818 males and 173 females) presumably unexposed to nerve agents. Median age was 42 (range, 18-76) years. RBC-AChE (mean ± SD) was 0.74±0.06 delta pH units/hour. Multivariate linear regression showed an association with age (slope 0.0008 delta pH units/hour for each year; P<0.001) unlikely to be clinically significant. The findings represent the largest study of human RBC-AChE to date providing measures of central tendency and variation.
KW - Acetylcholinesterase
KW - Human
KW - Red blood cell
UR - http://www.scopus.com/inward/record.url?scp=67349220937&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349220937&partnerID=8YFLogxK
U2 - 10.1080/01480540902863440
DO - 10.1080/01480540902863440
M3 - Article
C2 - 19538013
AN - SCOPUS:67349220937
VL - 32
SP - 182
EP - 185
JO - Drug and Chemical Toxicology
JF - Drug and Chemical Toxicology
SN - 0148-0545
IS - 3
ER -