Normal pituitary gland: II. Microscopic anatomy-CT correlation

H. M N Roppolo, Richard E Latchaw

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Pituitary microadenomas may present with subtle or no mass effect. They may appear lucent, dense, or heterogeneous on computed tomographic (CT) images. The normal pituitary gland may also have a nonhomogeneous CT appearance with intermingled lucent and dense areas. This heterogeneity is related in part to microscopic variation within the anterior and posterior lobes. Thirteen autopsy specimens of the pituitary gland were examined by coronal CT and histologically sectioned in similar coronal planes. The CT-lucent and CT-dense areas of the anterior and posterior lobes were correlated with corresponding areas on microscopic examination. To determine the effects of contrast infusion during CT, density measurements of lucent and dense areas in the anterior lobes of 25 normal contrast-enhanced pituitary glands in vivo were compared with density measurements of adjacent vascular structures at the time of scanning. Microscopic features corresponding to increased CT density in the anterior lobe included increased tissue compactness and increased cellular granularity, both of which usually occurred together in areas composed of tightly compacted and heavily granulated acidophilic cells. Conversely, microscopic features corresponding to decreased CT density in the anterior lobe included decreased tissue compactness and decreased cellular granularity, both of which frequently occurred together in areas containing chromophobic and/or mildly to moderately granulated basophilic cells. The degree of contrast enhancement within the anterior lobe appeared primarily to depend on vascularity, which in turn often depended on the degree of tissue compactness. In the posterior lobe, CT-lucent areas appeared to correspond to less compact and/or less vascular neurohypophyseal tissue.

Original languageEnglish (US)
Pages (from-to)937-944
Number of pages8
JournalAmerican Journal of Neuroradiology
Volume4
Issue number4
StatePublished - 1983
Externally publishedYes

Fingerprint

Pituitary Gland
Anatomy
Blood Vessels
Autopsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Normal pituitary gland : II. Microscopic anatomy-CT correlation. / Roppolo, H. M N; Latchaw, Richard E.

In: American Journal of Neuroradiology, Vol. 4, No. 4, 1983, p. 937-944.

Research output: Contribution to journalArticle

@article{817ebf28325842529618ef798da5d9b7,
title = "Normal pituitary gland: II. Microscopic anatomy-CT correlation",
abstract = "Pituitary microadenomas may present with subtle or no mass effect. They may appear lucent, dense, or heterogeneous on computed tomographic (CT) images. The normal pituitary gland may also have a nonhomogeneous CT appearance with intermingled lucent and dense areas. This heterogeneity is related in part to microscopic variation within the anterior and posterior lobes. Thirteen autopsy specimens of the pituitary gland were examined by coronal CT and histologically sectioned in similar coronal planes. The CT-lucent and CT-dense areas of the anterior and posterior lobes were correlated with corresponding areas on microscopic examination. To determine the effects of contrast infusion during CT, density measurements of lucent and dense areas in the anterior lobes of 25 normal contrast-enhanced pituitary glands in vivo were compared with density measurements of adjacent vascular structures at the time of scanning. Microscopic features corresponding to increased CT density in the anterior lobe included increased tissue compactness and increased cellular granularity, both of which usually occurred together in areas composed of tightly compacted and heavily granulated acidophilic cells. Conversely, microscopic features corresponding to decreased CT density in the anterior lobe included decreased tissue compactness and decreased cellular granularity, both of which frequently occurred together in areas containing chromophobic and/or mildly to moderately granulated basophilic cells. The degree of contrast enhancement within the anterior lobe appeared primarily to depend on vascularity, which in turn often depended on the degree of tissue compactness. In the posterior lobe, CT-lucent areas appeared to correspond to less compact and/or less vascular neurohypophyseal tissue.",
author = "Roppolo, {H. M N} and Latchaw, {Richard E}",
year = "1983",
language = "English (US)",
volume = "4",
pages = "937--944",
journal = "American Journal of Neuroradiology",
issn = "0195-6108",
publisher = "American Society of Neuroradiology",
number = "4",

}

TY - JOUR

T1 - Normal pituitary gland

T2 - II. Microscopic anatomy-CT correlation

AU - Roppolo, H. M N

AU - Latchaw, Richard E

PY - 1983

Y1 - 1983

N2 - Pituitary microadenomas may present with subtle or no mass effect. They may appear lucent, dense, or heterogeneous on computed tomographic (CT) images. The normal pituitary gland may also have a nonhomogeneous CT appearance with intermingled lucent and dense areas. This heterogeneity is related in part to microscopic variation within the anterior and posterior lobes. Thirteen autopsy specimens of the pituitary gland were examined by coronal CT and histologically sectioned in similar coronal planes. The CT-lucent and CT-dense areas of the anterior and posterior lobes were correlated with corresponding areas on microscopic examination. To determine the effects of contrast infusion during CT, density measurements of lucent and dense areas in the anterior lobes of 25 normal contrast-enhanced pituitary glands in vivo were compared with density measurements of adjacent vascular structures at the time of scanning. Microscopic features corresponding to increased CT density in the anterior lobe included increased tissue compactness and increased cellular granularity, both of which usually occurred together in areas composed of tightly compacted and heavily granulated acidophilic cells. Conversely, microscopic features corresponding to decreased CT density in the anterior lobe included decreased tissue compactness and decreased cellular granularity, both of which frequently occurred together in areas containing chromophobic and/or mildly to moderately granulated basophilic cells. The degree of contrast enhancement within the anterior lobe appeared primarily to depend on vascularity, which in turn often depended on the degree of tissue compactness. In the posterior lobe, CT-lucent areas appeared to correspond to less compact and/or less vascular neurohypophyseal tissue.

AB - Pituitary microadenomas may present with subtle or no mass effect. They may appear lucent, dense, or heterogeneous on computed tomographic (CT) images. The normal pituitary gland may also have a nonhomogeneous CT appearance with intermingled lucent and dense areas. This heterogeneity is related in part to microscopic variation within the anterior and posterior lobes. Thirteen autopsy specimens of the pituitary gland were examined by coronal CT and histologically sectioned in similar coronal planes. The CT-lucent and CT-dense areas of the anterior and posterior lobes were correlated with corresponding areas on microscopic examination. To determine the effects of contrast infusion during CT, density measurements of lucent and dense areas in the anterior lobes of 25 normal contrast-enhanced pituitary glands in vivo were compared with density measurements of adjacent vascular structures at the time of scanning. Microscopic features corresponding to increased CT density in the anterior lobe included increased tissue compactness and increased cellular granularity, both of which usually occurred together in areas composed of tightly compacted and heavily granulated acidophilic cells. Conversely, microscopic features corresponding to decreased CT density in the anterior lobe included decreased tissue compactness and decreased cellular granularity, both of which frequently occurred together in areas containing chromophobic and/or mildly to moderately granulated basophilic cells. The degree of contrast enhancement within the anterior lobe appeared primarily to depend on vascularity, which in turn often depended on the degree of tissue compactness. In the posterior lobe, CT-lucent areas appeared to correspond to less compact and/or less vascular neurohypophyseal tissue.

UR - http://www.scopus.com/inward/record.url?scp=0020959103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020959103&partnerID=8YFLogxK

M3 - Article

C2 - 6410878

AN - SCOPUS:0020959103

VL - 4

SP - 937

EP - 944

JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

SN - 0195-6108

IS - 4

ER -