Normal morphology and hormone receptor expression in the male California sea lion (Zalophus californianus) genital tract

Kathleen M. Colegrove, Frances M D Gulland, Diane K. Naydan, Linda J Lowenstine

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Histomorphology and estrogen α (ER α), and progesterone receptor (PR) expression were evaluated in free-ranging stranded male California sea lions (Zalophus californianus). Hormone receptor expression was evaluated using an immunohistochemical technique with monoclonal antibodies. Estrogen and PRs were identified in the efferent ductules, prostate gland, corpus cavernosa, corpus spongiosium, penile urethra, and in the epithelium and stroma of both the penis and prepuce. In some tissues, ER α expression was more intense in the stroma, emphasizing the importance of the stroma in hormone-mediated growth and differentiation of reproductive organs. To our knowledge, this is the first study to localize ER α and PR to the epithelium of the glans penis. The results of this investigation add to the general knowledge of male California sea lion reproduction and suggest that estrogens could have a role in the function of the male reproductive tract.

Original languageEnglish (US)
Pages (from-to)1818-1826
Number of pages9
JournalAnatomical Record
Volume292
Issue number11
DOIs
StatePublished - Nov 2009

Keywords

  • California sea lion
  • Estrogen receptor
  • Male reproductive tract
  • Progesterone receptor
  • Urogenital cancer

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Ecology, Evolution, Behavior and Systematics
  • Biotechnology

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