Normal left ventricular dimensions and function: Interstudy reproducibility of measurements with cine MR imaging

Richard C. Semelka, Ernesto Tomei, Stefan Wagner, John Mayo, Chisato Kondo, Jun Ichi Suzuki, Gary R. Caputo, Charles B. Higgins

Research output: Contribution to journalArticlepeer-review

351 Scopus citations


The authors evaluated the reproducibility of measurements of ventricular dimensions obtained with cine magnetic resonance (MR) imaging performed on two occasions in 11 healthy subjects. Two reviewers analyzed the studies in a blinded fashion to determine interobserver and interstudy variability of measurements of left ventricular (LV) mass, volume, ejection fraction, and systolic wall stress. LV mass showed good reproducibility between studies, with 3.6% and 3.8% variability for LV end-systolic mass for the two observers. LV end-diastolic volume varied by 5.2% and 3.9%, and LV end-systolic volume, by 9.7% and 9.0%. Variability for LV ejection fraction was 5.0% and 4.9%. The largest interstudy variability was end-systolic wall stress, 11.1% and 13.5%, which was due mostly to changes in arterial pressure between the two studies. It is concluded that anatomic and functional measurements from cine MR images are reproducible between studies. The small interstudy variability is likely related to the fact that the measurements are derived directly from cine MR images that encompass the entire heart rather than depend on measurements of only sample images and the use of geometric models.

Original languageEnglish (US)
Pages (from-to)763-768
Number of pages6
Issue number3
StatePublished - Mar 1990


  • Heart, ejection fraction
  • Heart, flow dynamics
  • Heart, function
  • Heart, MR studies, 524.1214
  • Heart, ventricles
  • Heart, volume
  • Magnetic resonance (MR), cine study, 524.1214

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology


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