Normal Aging of the Lung

Kent E Pinkerton, Francis H Y Green

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Citations (Scopus)

Abstract

This chapter focuses on the normal aging of lungs in various mammalian species such as mouse, rat, and dog. Various studies have demonstrated that lung aging in mice is associated with decreases in specific functional and structural parameters. These include increases in the phagocytic cell populations present in the lung airspaces, but decreased ability to engulf foreign particles. Decreases in antioxidant defense systems have also been noted in the lungs of aging mice. From a structural perspective, hyperinflation of the lungs and increases in interalveolar pore size and number are key features of the lung aging process in mice. The dynamics of lung growth, development, and aging in the rat is a continuous process that involves every tissue compartment of the lungs. Significant changes in aging adult rats are primarily within alveolar type II cells and the noncellular portions of the interstitium. Changes in cell number, size, and function associated with aging are likely to impact on lung physiology, metabolism, and immunity. Such changes could significantly alter the normal functions of the lung and its susceptibility to injury. Aging of canine lungs has many similarities to that seen in human lungs, but the aging process in dogs occurs over a shorter time frame than in humans. The accumulation of dust-laden macrophages as well as lumenal enlargement of alveolar ducts are hallmarks of this aging process. Changes in the relative velocity of mucus flow in the trachea with aging also parallels changes observed in the aging human trachea.

Original languageEnglish (US)
Title of host publicationThe Lung: Development, Aging and The Environment
PublisherElsevier Inc.
Pages213-233
Number of pages21
ISBN (Print)9780080481357, 9780123247513
DOIs
StatePublished - Dec 3 2003

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Lung
Trachea
Dogs
Alveolar Epithelial Cells
Mucus
Phagocytes
Dust
Cell Size
Growth and Development
Canidae
Immunity
Cell Count
Antioxidants
Macrophages
Wounds and Injuries
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pinkerton, K. E., & Green, F. H. Y. (2003). Normal Aging of the Lung. In The Lung: Development, Aging and The Environment (pp. 213-233). Elsevier Inc.. https://doi.org/10.1016/B978-012324751-3/50049-8

Normal Aging of the Lung. / Pinkerton, Kent E; Green, Francis H Y.

The Lung: Development, Aging and The Environment. Elsevier Inc., 2003. p. 213-233.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pinkerton, KE & Green, FHY 2003, Normal Aging of the Lung. in The Lung: Development, Aging and The Environment. Elsevier Inc., pp. 213-233. https://doi.org/10.1016/B978-012324751-3/50049-8
Pinkerton KE, Green FHY. Normal Aging of the Lung. In The Lung: Development, Aging and The Environment. Elsevier Inc. 2003. p. 213-233 https://doi.org/10.1016/B978-012324751-3/50049-8
Pinkerton, Kent E ; Green, Francis H Y. / Normal Aging of the Lung. The Lung: Development, Aging and The Environment. Elsevier Inc., 2003. pp. 213-233
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