Norepinephrine is required for the anticonvulsant effect of the ketogenic diet

Patricia Szot, David Weinshenker, Jong M. Rho, Thomas W. Storey, Philip A Schwartzkroin

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Ketogenic diet (KD) is a high fat, low carbohydrate diet used to treat children with epilepsy that are refractory to conventional antiepileptic drugs (AEDs). The anticonvulsant mechanism of the KD is unknown. To determine if the noradrenergic system has a role in mediating the anticonvulsant action of the KD, dopamine β-hydroxylase knockout (Dbh -/-) mice that lack norepinephrine (NE) and Dbh +/- littermates that have normal NE content were fed either a standard rodent chow or the KD. When exposed to the convulsant flurothyl, Dbh +/- mice fed the KD had significantly longer latencies to myoclonic jerk (MJ) and generalized clonic-tonic (CT) seizures than Dbh +/- mice fed normal chow. In contrast, Dbh -/- mice fed the KD had seizure latencies to both MJ and CT comparable to Dbh -/- mice fed normal chow. These results suggest that an intact, functional noradrenergic nervous system is required for the KD to exert an anticonvulsant effect.

Original languageEnglish (US)
Pages (from-to)211-214
Number of pages4
JournalDevelopmental Brain Research
Volume129
Issue number2
DOIs
StatePublished - Aug 23 2001
Externally publishedYes

Fingerprint

Ketogenic Diet
Anticonvulsants
Norepinephrine
Myoclonus
Seizures
Flurothyl
Carbohydrate-Restricted Diet
Convulsants
Mixed Function Oxygenases
Knockout Mice
Nervous System
Rodentia
Epilepsy
Dopamine
Fats

Keywords

  • Dopamine β-hydroxylase
  • Flurothyl
  • Ketogenic diet
  • Mouse
  • Norepinephrine
  • Pediatric epilepsy

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Norepinephrine is required for the anticonvulsant effect of the ketogenic diet. / Szot, Patricia; Weinshenker, David; Rho, Jong M.; Storey, Thomas W.; Schwartzkroin, Philip A.

In: Developmental Brain Research, Vol. 129, No. 2, 23.08.2001, p. 211-214.

Research output: Contribution to journalArticle

Szot, Patricia ; Weinshenker, David ; Rho, Jong M. ; Storey, Thomas W. ; Schwartzkroin, Philip A. / Norepinephrine is required for the anticonvulsant effect of the ketogenic diet. In: Developmental Brain Research. 2001 ; Vol. 129, No. 2. pp. 211-214.
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