Abstract
Ketogenic diet (KD) is a high fat, low carbohydrate diet used to treat children with epilepsy that are refractory to conventional antiepileptic drugs (AEDs). The anticonvulsant mechanism of the KD is unknown. To determine if the noradrenergic system has a role in mediating the anticonvulsant action of the KD, dopamine β-hydroxylase knockout (Dbh -/-) mice that lack norepinephrine (NE) and Dbh +/- littermates that have normal NE content were fed either a standard rodent chow or the KD. When exposed to the convulsant flurothyl, Dbh +/- mice fed the KD had significantly longer latencies to myoclonic jerk (MJ) and generalized clonic-tonic (CT) seizures than Dbh +/- mice fed normal chow. In contrast, Dbh -/- mice fed the KD had seizure latencies to both MJ and CT comparable to Dbh -/- mice fed normal chow. These results suggest that an intact, functional noradrenergic nervous system is required for the KD to exert an anticonvulsant effect.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 211-214 |
| Number of pages | 4 |
| Journal | Developmental Brain Research |
| Volume | 129 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 23 2001 |
| Externally published | Yes |
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Keywords
- Dopamine β-hydroxylase
- Flurothyl
- Ketogenic diet
- Mouse
- Norepinephrine
- Pediatric epilepsy
ASJC Scopus subject areas
- Developmental Biology
- Developmental Neuroscience
Cite this
Norepinephrine is required for the anticonvulsant effect of the ketogenic diet. / Szot, Patricia; Weinshenker, David; Rho, Jong M.; Storey, Thomas W.; Schwartzkroin, Philip A.
In: Developmental Brain Research, Vol. 129, No. 2, 23.08.2001, p. 211-214.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Norepinephrine is required for the anticonvulsant effect of the ketogenic diet
AU - Szot, Patricia
AU - Weinshenker, David
AU - Rho, Jong M.
AU - Storey, Thomas W.
AU - Schwartzkroin, Philip A
PY - 2001/8/23
Y1 - 2001/8/23
N2 - Ketogenic diet (KD) is a high fat, low carbohydrate diet used to treat children with epilepsy that are refractory to conventional antiepileptic drugs (AEDs). The anticonvulsant mechanism of the KD is unknown. To determine if the noradrenergic system has a role in mediating the anticonvulsant action of the KD, dopamine β-hydroxylase knockout (Dbh -/-) mice that lack norepinephrine (NE) and Dbh +/- littermates that have normal NE content were fed either a standard rodent chow or the KD. When exposed to the convulsant flurothyl, Dbh +/- mice fed the KD had significantly longer latencies to myoclonic jerk (MJ) and generalized clonic-tonic (CT) seizures than Dbh +/- mice fed normal chow. In contrast, Dbh -/- mice fed the KD had seizure latencies to both MJ and CT comparable to Dbh -/- mice fed normal chow. These results suggest that an intact, functional noradrenergic nervous system is required for the KD to exert an anticonvulsant effect.
AB - Ketogenic diet (KD) is a high fat, low carbohydrate diet used to treat children with epilepsy that are refractory to conventional antiepileptic drugs (AEDs). The anticonvulsant mechanism of the KD is unknown. To determine if the noradrenergic system has a role in mediating the anticonvulsant action of the KD, dopamine β-hydroxylase knockout (Dbh -/-) mice that lack norepinephrine (NE) and Dbh +/- littermates that have normal NE content were fed either a standard rodent chow or the KD. When exposed to the convulsant flurothyl, Dbh +/- mice fed the KD had significantly longer latencies to myoclonic jerk (MJ) and generalized clonic-tonic (CT) seizures than Dbh +/- mice fed normal chow. In contrast, Dbh -/- mice fed the KD had seizure latencies to both MJ and CT comparable to Dbh -/- mice fed normal chow. These results suggest that an intact, functional noradrenergic nervous system is required for the KD to exert an anticonvulsant effect.
KW - Dopamine β-hydroxylase
KW - Flurothyl
KW - Ketogenic diet
KW - Mouse
KW - Norepinephrine
KW - Pediatric epilepsy
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UR - http://www.scopus.com/inward/citedby.url?scp=0035939996&partnerID=8YFLogxK
U2 - 10.1016/S0165-3806(01)00213-9
DO - 10.1016/S0165-3806(01)00213-9
M3 - Article
VL - 129
SP - 211
EP - 214
JO - Developmental Brain Research
JF - Developmental Brain Research
SN - 0165-3806
IS - 2
ER -